Results 151 to 160 of about 266,703 (299)

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, EarlyView.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

From Fuel to Flow: Translating the Beneficial Hemodynamic Effects of Exogenous Ketones in the ICU. [PDF]

JACC Heart Fail
Elliott DM, Katz JN, Selvaraj S.
europepmc   +1 more source

Oxytocin‐ und Vasopressin‐Photosonden zur Entschlüsselung der Neuropeptid‐Signalgebung mit hoher räumlicher und zeitlicher Präzision

Angewandte Chemie, EarlyView.
Neue biokompatible Oxytocin‐ und Vasopressin‐Photosonden mit modernsten Photocages. Diese Photosonden sind inaktiv und können mit spezifischen Lichtwellen entschützt werden, was eine Rezeptoraktivierung mit hoher zeitlicher und räumlicher Kontrolle ermöglicht. Abbildung erstellt mit https://BioRender.com ZUSAMMENFASSUNG Das Oxytocin/Vasopressin (OT/VP)
Konstantin Raabe, Predrag Kalaba, Xuan Ling Hilary Yong, Greta Crudeli, Sarah Melzer, Erik Keimpema, Victor Anggono, Markus Muttenthaler   +7 more
wiley   +1 more source

The effect of exogenous ketone bodies on cognition across health and disease: a systematic review and meta-analysis. [PDF]

Front Nutr
Bonnechère B, Stephens EB, Boileau AC, Ducker M, Stubbs BJ.   +4 more
europepmc   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Current practices of SGLT2 inhibitor use and ketone monitoring in intensive care units: A multicentre observational study. [PDF]

Crit Care Resusc
Sasaki T, Micallef S, Wang AY, Butt F, Hammond NE, Hardie M, Knowles S, Yokoo T, Gallagher M, George Institute for Global Health and the Australian and New Zealand Intensive Care Society Clinical Trials Group.   +9 more
europepmc   +1 more source

Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening

Angewandte Chemie, EarlyView.
Through historical context and recent examples, this Minireview summarizes the strengths, limitations, and practical considerations for the implementation of substrate multiplexed screening (SUMS) in enzyme evolution. ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate ...
Holly A. Weilbaker, Meghan E. Campbell, Peyton M. Higgins, Andrew R. Buller   +3 more
wiley   +2 more sources

Radikale Kaskadenreaktion, welche die Kreuzkupplung von Olefinen mit der Smiles‐Truce‐Umlagerung kombiniert

Angewandte Chemie, EarlyView.
Wir stellen eine kobaltkatalysierte Radikalkaskade vor, die zwei Alken Ausgangsstoffe effizient miteinander verbindet und so in einem einzigen Schritt mehrere Bindungen aufbaut. Der Prozess beginnt mit einem kobaltkatalysierten Wasserstoffatomtransfer an eine Styrol‐Doppelbindung, gefolgt von einer Giese‐Addition.
Jingyang Qin, Lucas Popek, Moritz Wyrtki, Christopher J. Teskey   +3 more
wiley   +1 more source

Preliminary study on ketone body metabolism in anaplastic thyroid cancer. [PDF]

Eur Thyroid J
Wang J, Mao Y, Xuan Z, Li Z, Tang X, Yang K, Xing M, Zhu X.   +7 more
europepmc   +1 more source

Catalytic enantioselective alkene epoxidation using novel spirocyclic N-carbethoxy-azabicyclo[3.2.1]octanones

, 2010
Armstrong, A, Bettati, M, White, AJP
core   +1 more source