Results 101 to 110 of about 29,891 (282)

A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting [PDF]

, 2012
Sarah E. Hugo, Lourdes Cruz-Garcia, Santhosh Karanth, Ryan M. Anderson, Didier Y. R. Stainier, Amnon Schlegel   +5 more
openalex   +1 more source

A Miniature Rotary Electrostatic Clutch for Assigning Multi‐Degrees of Freedom to Insect‐Scale Robots

Advanced Intelligent Systems, EarlyView.
Insect‐scale crawling robots can traverse confined environments; nevertheless, their functionalities are predominantly restricted to sensing because of challenges in integrating actuated degrees of freedom. Herein, a miniature rotary electrostatic clutch is presented by incorporating cutting patterns in the clutch layer.
Jongeun Lee, Amir Firouzeh, Seunghyun An, Pilwoo Lee, Kyu‐Jin Cho   +4 more
wiley   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Hyperketonemia-Ketogenesis and Ketone Body Metabolism

Journal of Dairy Science, 1971
Abstract In bovine ketosis, hyperketonemia is only one biochemical disturbance that occurs among a multiplicity of metabolic changes. The changes can be grouped into two major categories and these are: 1) a reduction in available carbohydrate and 2) an increase in the quantities of fat and ketone bodies being metabolized.
openaire   +2 more sources

Role of FFAR3 in ketone body regulated glucagon-like peptide 1 secretion

Biochemistry and Biophysics Reports
Background: Roux-en-Y gastric bypass (RYGB) is an effective treatment for obesity, resulting in long-term weight loss and rapid remission of type 2 diabetes mellitus.
Sara MT. Persson, Anna Casselbrant, Aiham Alarai, Erik Elebring, Lars Fändriks, Ville Wallenius   +5 more
doaj   +1 more source

Ketone bodies in exercise, health and disease: Metabolic mechanisms, pathophysiology, and therapeutic implications

Advanced Exercise and Health Science
Ketone bodies (KBs) are alternative metabolic fuels predominantly produced in the liver during periods of carbohydrate restriction, prolonged fasting, or ketogenic dietary intake.
Yin Li, Qingyi Liu, Zhihao Jia, Bin Guo
doaj   +1 more source

AMPKα2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation

Scientific Reports
Ketone bodies serve as an energy source, especially in the absence of carbohydrates or in the extended exercise. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a crucial energy sensor that regulates lipid and glucose metabolism. However,
Lingxue Zhang, Yanqiao Lu, Junqing An, Yin Wu, Zhixue Liu, Ming-Hui Zou   +5 more
doaj   +1 more source

Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis [PDF]

, 2017
T. Salomon, Christian Sibbersen, Jakob Hansen, Dieter Britz, Mads Svart, Thomas Schmidt Voss, Niels Møller, Niels Gregersen, Karl Anker Jørgensen, Johan Palmfeldt, Thomas B. Poulsen, Mogens Johannsen   +11 more
openalex   +1 more source

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

Animal Research and One Health, EarlyView.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng, GuoYan Wang, YuanYuan Zhu, YiNing Zheng, JunHu Yao, Lei Chen, Lu Deng   +6 more
wiley   +1 more source