Results 231 to 240 of about 57,304 (300)

Discovery of periplasmic solute binding proteins with specificity for ketone bodies: β-hydroxybutyrate binding proteins. [PDF]

Protein Sci
Kane BJ, Okuda-Shimazaki J, Andrews MM, Kerrigan JA, Murphy KV, Sode K.   +5 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Ketone Bodies Are Potential Prognostic Biomarkers in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Results from the R2-GDP-GOTEL Trial. [PDF]

Cancers (Basel)
Fernández-Castillejo S, Badia J, de la Cruz-Merino L, Martín Garcia-Sáncho A, Carnicero-González F, Palazón-Carrión N, Ríos-Herranz E, de la Cruz-Vicente F, Rueda-Domínguez A, Martínez-Banaclocha N, Gómez-Codina J, Labrador J, Martínez-Madueño F, Amigó N, Salar-Silvestre A, Rodríguez-Abreu D, Gálvez-Carvajal L, Sánchez-Beato M, Provencio-Pulla M, Guirado-Risueño M, Nogales E, Sánchez-Margalet V, Jiménez-Cortegana C, Rodríguez-García G, Cumeras R, Gumà J, Spanish Lymphoma Oncology Group (GOTEL).   +26 more
europepmc   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source

Circulating ketone bodies and mortality in heart failure: a community cohort study. [PDF]

Front Cardiovasc Med
Oyetoro RO, Conners KM, Joo J, Turecamo S, Sampson M, Wolska A, Remaley AT, Otvos JD, Connelly MA, Larson NB, Bielinski SJ, Hashemian M, Shearer JJ, Roger VL.   +13 more
europepmc   +1 more source

Accuracy (Trueness and Precision) of the Calibrated Intraoral Scan Protocol: An In Vitro Comparison of Three Scan Calibrator Designs In an Edentulous Implant Model

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives To introduce a universal scan calibrator (SC) and to evaluate its accuracy in the calibrated intraoral scan protocol (CISP) by comparison with two previously published SCs. Materials and Methods Three SCs were evaluated on an edentulous implant model containing six scan bodies (SBs) positioned at the screw‐retained abutment (SRA ...
Shengtao Yang, Chenyi Zhang, Yan Bao, Shuo Wang, Lei Chi, Li Yue, Quan Yuan, Junying Li   +7 more
wiley   +1 more source

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet, Iain K. Robertson, Sharon P. Luccisano, Michelle L. Kilpatrick   +3 more
wiley   +1 more source

Hyperglycemia Stimulates the Irreversible Catabolism of Branched-Chain Amino Acids and Generation of Ketone Bodies by Cultured Human Astrocytes. [PDF]

Biomedicines
Gondáš E, Baranovičová E, Baranovičová E, Šofranko J, Murín R.   +4 more
europepmc   +1 more source

A consensus statement on a National Competency Framework for training and assessment of knowledge and skills in diabetes technologies, including hybrid closed loop (HCL), insulin pump systems, and continuous glucose monitoring (CGM) devices

Diabetic Medicine, EarlyView.
Abstract Aims To design a national competency framework supporting the training of healthcare professionals (HCP) in the care and management of people with diabetes using diabetes technologies. Methods Following the release of the NICE [TA943] guidance1 and the NHS England 5‐year implementation strategy2, a working group was formed to design a four ...
E. Richardson, B. Stribling, J. Ridgeway, C. Kitching‐Davis, L. Willcocks, L. Heggs, H. Wakefield, G. Gallen, A. Jolley, K. Bareford, A. Williams, D. Farrow, T. Fletcher‐Salt, D. Hicks, J. Higgins, L. Jordan, B. Kelly, C. Metcalf‐O’Shea, M. Turner, E. Walden, A. Walker, P. Choudhary   +21 more
wiley   +1 more source