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Ketone bodies in cell physiology and cancer
American Journal of Physiology - Cell PhysiologyKetogenic diets (KDs), fasting, or prolonged physical activity elevate serum ketone bodies (KBs) levels, providing an alternative fuel source for the brain and other organs. However, KBs play pleiotropic roles that go beyond their role in energy production.
Valter Longo
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Nonalcoholic fatty liver disease, circulating ketone bodies and all‐cause mortality in a general population‐based cohort [PDF]
European Journal of Clinical Investigation, 2021 Background Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent, paralleling the obesity epidemic. Ketone bodies are produced in the liver, but it is currently uncertain whether circulating ketone bodies are increased in the context of ...
Adrian Post +2 more
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Metabolic Messengers: ketone bodies
Nature Metabolism, 2023Prospective molecular targets and therapeutic applications for ketone body metabolism have increased exponentially in the past decade. Initially considered to be restricted in scope as liver-derived alternative fuel sources during periods of carbohydrate restriction or as toxic mediators during diabetic ketotic states, ketogenesis and ketone bodies ...
Alisa B. Nelson +3 more
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Ketone bodies for the starving heart
Nature Metabolism, 2020The heart is an organ with high energy demands and metabolic flexibility, thus allowing for various energy substrates for ATP production under different physiological conditions. Zhang et al., Fernandez-Caggiano et al. and McCommis et al. converge on the mitochondrial pyruvate transporter as a key metabolic hub for the maintenance of cardiac metabolism
P. Christian Schulze, Jasmine M. F. Wu
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Ketone bodies as epigenetic modifiers
Current Opinion in Clinical Nutrition & Metabolic Care, 2018Ketone body metabolism is a dynamic and integrated metabolic node in human physiology, whose roles include but extend beyond alternative fuel provision during carbohydrate restriction. Here we discuss the most recent observations suggesting that ketosis coordinates cellular function via epigenomic regulation.Ketosis has been linked to covalent ...
Hai-Bin, Ruan, Peter A, Crawford
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Cerebral ketone body metabolism
Journal of Inherited Metabolic Disease, 2004SummaryKetone bodies (KBs) are an important source of energy for the brain. During the neonatal period, they are also precursors for the synthesis of lipids (especially cholesterol) and amino acids. The rate of cerebral KB metabolism depends primarily on the concentration in blood; high concentrations occur during fasting and on a high‐fat diet ...
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Neuroprotective Properties of Ketone Bodies
2011Ketosis, as with fasting or induced by ketogenic diet, continues to be explored as a strategy toward the treatment of neuropathologies and disease. Exogenous administration of anaplerotic compounds has shown promise as they rescue oxidatively stressed tissues and has shown to improve overall function in liver and heart, but little is known about their ...
Kui, Xu +2 more
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Diabetes Research and Clinical Practice, 2006
Abstract Diabetic ketoacidosis (DK) is a serious acute complication in type 1 diabetic patients caused by insulin deficiency. The early detection of insulin deprivation represents therefore an important element in routine clinical practice, especially in ketone prone subjects such as CSII (continuous subcutaneous insulin infusion) treated subjects ...
Marco Orsini Federici +1 more
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Abstract Diabetic ketoacidosis (DK) is a serious acute complication in type 1 diabetic patients caused by insulin deficiency. The early detection of insulin deprivation represents therefore an important element in routine clinical practice, especially in ketone prone subjects such as CSII (continuous subcutaneous insulin infusion) treated subjects ...
Marco Orsini Federici +1 more
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Intermittent fasting and ketone bodies
Intermittent fasting (IF) is a dietary intervention based on time-restricted energy intake. Over the years, IF has been widely investigated as a non-pharmacological approach to increasing life expectancy and promoting brain health. The underlying mechanisms by which IF promotes its beneficial effects are attributed to hormesis, an evolutionary adaptiveGeovana Rosa, Oliveira Dos Santos +3 more
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The chemical estimation of ketone bodies
Analytical Biochemistry, 1966Abstract A chemical method for the estimation of ketone bodies is described in which the ketone bodies are converted to acetone and estimated as acetonc 2,4-dinitrophenylhydrazone. The method is of particularly high sensitivity and appears to possess adequate specificity.
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