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Fasting Plasma Ketone Bodies Are Associated with NT-proBNP: A Potential Mechanism to Provide Fuel for the Failing Heart. [PDF]
J Clin MedPalm CL +5 more
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Opposite kinetics of L-leucine and L-phenylalanine induced insulin release studies with the perfused rat pancreas [PDF]
, 1972 Landgraf, R. +3 more
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Metabolic Messengers: ketone bodies
Nature Metabolism, 2023Prospective molecular targets and therapeutic applications for ketone body metabolism have increased exponentially in the past decade. Initially considered to be restricted in scope as liver-derived alternative fuel sources during periods of carbohydrate restriction or as toxic mediators during diabetic ketotic states, ketogenesis and ketone bodies ...
Alisa B. Nelson +3 more
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Diabetes Research and Clinical Practice, 2006
Abstract Diabetic ketoacidosis (DK) is a serious acute complication in type 1 diabetic patients caused by insulin deficiency. The early detection of insulin deprivation represents therefore an important element in routine clinical practice, especially in ketone prone subjects such as CSII (continuous subcutaneous insulin infusion) treated subjects ...
Marco Orsini Federici +1 more
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Abstract Diabetic ketoacidosis (DK) is a serious acute complication in type 1 diabetic patients caused by insulin deficiency. The early detection of insulin deprivation represents therefore an important element in routine clinical practice, especially in ketone prone subjects such as CSII (continuous subcutaneous insulin infusion) treated subjects ...
Marco Orsini Federici +1 more
openaire +1 more source
Cerebral ketone body metabolism
Journal of Inherited Metabolic Disease, 2004SummaryKetone bodies (KBs) are an important source of energy for the brain. During the neonatal period, they are also precursors for the synthesis of lipids (especially cholesterol) and amino acids. The rate of cerebral KB metabolism depends primarily on the concentration in blood; high concentrations occur during fasting and on a high‐fat diet ...
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Ketone bodies as epigenetic modifiers
Current Opinion in Clinical Nutrition & Metabolic Care, 2018Ketone body metabolism is a dynamic and integrated metabolic node in human physiology, whose roles include but extend beyond alternative fuel provision during carbohydrate restriction. Here we discuss the most recent observations suggesting that ketosis coordinates cellular function via epigenomic regulation.Ketosis has been linked to covalent ...
Hai-Bin, Ruan, Peter A, Crawford
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Bedside Blood Ketone Body Monitoring
Diabetic Medicine, 1991The use of a reagent strip and reflectance meter for the bedside measurement of 3‐hydroxybutyrate during the clinical management of diabetic ketoacidosis is described. Comparison of this method with a laboratory enzymatic assay shows good correlation (r = 0.97, p < 0.05). Initial use in acute ketoacidosis suggests that knowledge of hourly changes in
M O, McBride +3 more
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Neuroprotective Properties of Ketone Bodies
2011Ketosis, as with fasting or induced by ketogenic diet, continues to be explored as a strategy toward the treatment of neuropathologies and disease. Exogenous administration of anaplerotic compounds has shown promise as they rescue oxidatively stressed tissues and has shown to improve overall function in liver and heart, but little is known about their ...
Kui, Xu +2 more
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