Results 31 to 40 of about 29,891 (282)

SLC16a6, mTORC1, and Autophagy Regulate Ketone Body Excretion in the Intestinal Cells

Biology, 2023
Ketone bodies serve several functions in the intestinal epithelium, such as stem cell maintenance, cell proliferation and differentiation, and cancer growth.
Takashi Uebanso, Moeka Fukui, Chisato Naito, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi   +5 more
doaj   +1 more source

Exploring the role of ketone bodies in the diagnosis and treatment of psychiatric disorders

Frontiers in Psychiatry, 2023
In recent times, advances in the field of metabolomics have shed greater light on the role of metabolic disturbances in neuropsychiatric conditions. The following review explores the role of ketone bodies and ketosis in both the diagnosis and treatment ...
Naomi Elyse Omori, Mantas Kazimieras Malys, Geoffrey Woo, Latt Mansor   +3 more
doaj   +1 more source

Ketone Bodies Stimulate Chaperone-mediatedAutophagy [PDF]

Journal of Biological Chemistry, 2005
Chaperone-mediated autophagy (CMA) is a selective lysosomal protein degradative process that is activated in higher organisms under conditions of prolonged starvation and in cell culture by the removal of serum. Ketone bodies are comprised of three compounds (beta-hydroxybutyrate, acetoacetate, and acetone) that circulate during starvation, especially ...
Patrick F, Finn, J Fred, Dice
openaire   +2 more sources

Ketone Body Metabolism in the Ischemic Heart

Frontiers in Cardiovascular Medicine, 2021
Ketone bodies have been identified as an important, alternative fuel source in heart failure. In addition, the use of ketone bodies as a fuel source has been suggested to be a potential ergogenic aid for endurance exercise performance.
Stephen C. Kolwicz
doaj   +1 more source

Pathophysiological Abnormalities in Migraine Ameliorated by Ketosis: A Proof-of-Concept Review

Journal of Integrative Neuroscience, 2022
Migraine is a prevalent heterogeneous neurological disorder, enumerated as the eighth most disabling neurological disorder by the World Health Organization.
Panitda Huynh, Pasquale Calabrese
doaj   +1 more source

Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms

Frontiers in Neurology, 2019
There is growing evidence that ketone bodies, which are derived from fatty acid oxidation and usually produced in fasting state or on high-fat diets have broad neuroprotective effects.
Huajun Yang, Huajun Yang, Wei Shan, Wei Shan, Wei Shan, Wei Shan, Fei Zhu, Fei Zhu, Jianping Wu, Jianping Wu, Jianping Wu, Qun Wang, Qun Wang, Qun Wang, Qun Wang   +14 more
doaj   +1 more source

Characteristics of Cardiac Ketone Body Metabolism Throughout the Life Cycle

Cardiovascular Therapeutics
Ketone bodies can serve as energy substrates for the heart and perform important molecular signal transduction functions. In recent years, the therapeutic potential of ketone bodies has become a research hotspot in the field of cardiovascular diseases ...
Lei Li, Xiaojian Song, Xiurui Ma, Yanwu Xu   +3 more
doaj   +1 more source

Elevated Plasma Levels of Ketone Bodies Are Associated With All‐Cause Mortality and Incidence of Heart Failure in Older Adults: The CHS

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Chronic disease, such as heart failure, influences cellular metabolism and shapes circulating metabolites. The relationships between key energy metabolites and chronic diseases in aging are not well understood. This study aims to determine the
Sebastian Niezen, Margery A. Connelly, Calvin Hirsch, Jorge R. Kizer, Maria E. Benitez, Scott Minchenberg, Maria Camila Perez‐Matos, Zhenghui Gordon Jiang, Kenneth J. Mukamal   +8 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Relationships between milk ketone bodies and selected milk indicators during conventional and extended lactation [PDF]

Journal of Central European Agriculture
During lactation, dairy cows undergo various metabolic changes that are reflected not only in milk yield but also in milk composition. This study aimed to determine the milk performance and composition depending on the stage of lactation and describe ...
Karolína REINDL, Lucie HASOŇOVÁ, Roman KONEČNÝ, Michaela HORČIČKOVÁ, Jan TRÁVNÍČEK, Natalia CLIMOVA, Simona JANOUŠEK HONESOVÁ, Martin KVÁČ, Jindřich ČÍTEK, Oto HANUŠ, Eva SAMKOVÁ   +10 more
doaj   +1 more source