Nutrients, 2020 Ketone bodies (KBs), comprising β-hydroxybutyrate, acetoacetate and acetone, are a set of fuel molecules serving as an alternative energy source to glucose. KBs are mainly produced by the liver from fatty acids during periods of fasting, and prolonged or
Arkadiusz Dąbek +3 more
semanticscholar +1 more source
Cerebral Ketone Body Oxidation Is Facilitated by a High Fat Diet Enriched with Advanced Glycation End Products in Normal and Diabetic Rats. [PDF]
, 2016 Diabetes mellitus (DM) causes important modifications in the availability and use of different energy substrates in various organs and tissues. Similarly, dietary manipulations such as high fat diets also affect systemic energy metabolism.
Adriano Martimbianco De Assis +12 more
core +1 more source
Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade
JCI Insight, 2020 Limited experimental evidence bridges nutrition and cancer immunosurveillance. Here, we show that ketogenic diet (KD) — or its principal ketone body, 3-hydroxybutyrate (3HB), most specifically in intermittent scheduling — induced T cell–dependent tumor ...
Gladys Ferrere +27 more
semanticscholar +1 more source
Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity. [PDF]
, 2014 n mammals, extended periods of fasting leads to the accumulation of blood ketone bodies including acetoacetate. Here we show that similar to the conversion of leucine to acetoacetate in fasting mammals, starvation conditions induced ketone body-like ...
Amparo C +8 more
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Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature [PDF]
, 2020 Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease, characterized by hepatic fat accumulation and possible development of inflammation, fibrosis, and cancer. The ketogenic diet (KD), with its drastic carbohydrate reduction,
Basciani, Sabrina +8 more
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Anti-oxidant and anti-inflammatory activity of ketogenic diet. New perspectives for neuroprotection in alzheimer’s disease [PDF]
, 2018 The ketogenic diet, originally developed for the treatment of epilepsy in non-responder children, is spreading to be used in the treatment of many diseases, including Alzheimer’s disease.
Bonucci, Alessio +4 more
core +1 more source
Urine ketone bodies and adverse outcomes in patients with acute ischemic stroke or TIA
Atherosclerosis Plus, 2022 Background and aims: Urine ketone bodies have been considered as predictors of stroke in diabetic patients, however, the role of urine ketone bodies in the prognosis of stroke has not been investigated well.
Anxin Wang +7 more
doaj
HMGCS2 is a key ketogenic enzyme potentially involved in type 1 diabetes with high cardiovascular risk. [PDF]
, 2017 Diabetes increases the risk of Cardio-vascular disease (CVD). CVD is more prevalent in type 2 diabetes (T2D) than type 1 diabetes (T1D), but the mortality risk is higher in T1D than in T2D. The pathophysiology of CVD in T1D is poorly defined.
Addya, Sankar +6 more
core +2 more sources
Journal of Obesity & Metabolic Syndrome, 2020 Background : Ketone bodies are a well-known metabolite from the utilization of fatty acids in the fasting state. Some studies have demonstrated the metabolic benefits of urinary ketones in a specific population in whom ketone bodies were detected ...
Jong-Min Han, Nam-Seok Joo
doaj +1 more source
SLC16a6, mTORC1, and Autophagy Regulate Ketone Body Excretion in the Intestinal Cells
Biology, 2023 Ketone bodies serve several functions in the intestinal epithelium, such as stem cell maintenance, cell proliferation and differentiation, and cancer growth.
Takashi Uebanso +5 more
doaj +1 more source