Results 71 to 80 of about 4,666,601 (266)

The Role of Exogenous Ketones in Road Cycling: Evidence, Mechanisms, and Performance Claims

Physiologia
Background: Ketone body supplementation has emerged as a potential ergogenic aid in cycling. Exogenous ketones, primarily in the form of beta-hydroxybutyrate, offer an alternative fuel source, bypassing the need for strict ketogenic diets.
Sebastian Sitko
doaj   +1 more source

Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives

Frontiers in Neuroscience, 2019
The ketogenic diet (KD) is a high-fat, low-carbohydrate treatment for medically intractable epilepsy. One of the hallmark features of the KD is the production of ketone bodies which have long been believed, but not yet proven, to exert direct anti ...
Angela M. Poff, Jong M. Rho, Jong M. Rho, Dominic P. D’Agostino, Dominic P. D’Agostino   +4 more
doaj   +1 more source

Starvation of Cancer via Induced Ketogenesis and Severe Hypoglycemia

, 2014
Neoplasms are highly dependent on glucose as their substrate for energy production and are generally not able to catabolize other fuel sources such as ketones and fatty acids.
Kapelner, Adam, Vorsanger, Matthew
core   +1 more source

Ketone Bodies, Potential Therapeutic Uses [PDF]

IUBMB Life, 2001
AbstractKetosis, meaning elevation of D‐ β‐hydroxybutyrate ( R ‐3‐hydroxybutyrate) and acetoacetate, has been central to starving man's survival by providing nonglucose substrate to his evolutionarily hypertrophied brain, sparing muscle from destruction for glucose synthesis.
Yoshihiro Kashiwaya, Henry A. Lardy, Richard L. Veech, Britton Chance, George F. Cahill   +4 more
openaire   +2 more sources

Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neurons in vitro

Frontiers in Neurology, 2019
Objectives: Despite the long-term efficacy of antiepileptic drug treatments, frequent attacks of drug-resistant epilepsy necessitate the development of new antiepileptic drug therapy targets.
Fei Zhu, Fei Zhu, Fei Zhu, Fei Zhu, Wei Shan, Wei Shan, Wei Shan, Wei Shan, Qinlan Xu, Qinlan Xu, Qinlan Xu, Anchen Guo, Anchen Guo, Jianping Wu, Jianping Wu, Jianping Wu, Qun Wang, Qun Wang, Qun Wang   +18 more
doaj   +1 more source

Impact of ketogenic diet and ketone diester supplementation on body weight, blood glucose, and ketones in Sprague Dawley rats fed over two weeks

Food Chemistry: Molecular Sciences, 2021
Ketogenic diets consist of low carbohydrate/high fat, shifting energy reliance from glucose to ketone bodies. Ketone diester supplement to a standard diet (ketone ester) increases ketone bodies by adding a substance without altering other consumed foods.
LT Claire M. Modica, Krystal Flores-Felix, LT John D. Casachahua, Paul Asquith, Anna Tschiffely, Stephanie Ciarlone, Stephen T. Ahlers   +6 more
doaj  

Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice

Molecular Metabolism, 2021
Objective: Throughout the last decade, interest has intensified in intermittent fasting, ketogenic diets, and exogenous ketone therapies as prospective health-promoting, therapeutic, and performance-enhancing agents.
David B. Stagg, Jacob R. Gillingham, Alisa B. Nelson, Justin E. Lengfeld, D. André d’Avignon, Patrycja Puchalska, Peter A. Crawford   +6 more
doaj  

Ketogenic diet-induced weight loss is associated with an increase in vitamin d levels in obese adults [PDF]

, 2019
Vitamin D is an important micronutrient involved in several processes. Evidence has shown a strong association between hypovitaminosis D and cardio-metabolic diseases, including obesity.
Gigliotti, S, Maio, R, Perticone, F., Perticone, M, Pinto, A, Pujia, R, Sciacqua, A, Sesti, G, Suraci, E, Zito, R   +9 more
core   +1 more source

Determination of 14C radioactivity in ketone bodies: a new, simplified method and its validation.

Journal of Lipid Research, 1980
A rapid and reproducible method for the assay of 14C radioactivity in ketone bodies is described, based on the heat lability of acetoacetate and the ability of beta-hydroxybutyrate to quantitatively bind to and elute from an ion exchange resin. Potential
J M Miles, M W Haymond, R A Rizza, J E Gerich   +3 more
doaj  

Metabolic Effects of the Very-Low-Carbohydrate Diets: Misunderstood "Villains" of Human Metabolism

Journal of the International Society of Sports Nutrition, 2004
During very low carbohydrate intake, the regulated and controlled production of ketone bodies causes a harmless physiological state known as dietary ketosis. Ketone bodies flow from the liver to extra-hepatic tissues (e.g., brain) for use as a fuel; this
Manninen Anssi H
doaj   +1 more source