Results 41 to 50 of about 114,544 (214)

α-Heteroarylthiomethyl ketones: Small molecule inhibitors of 3CLpro

Acta Pharmaceutica
The main protease 3CLpro of the SARS-CoV-2 virus is a well--established therapeutic target for the treatment of COVID-19. In this study, we screened an in-house compound library and identified a series of α-heteroarylthiomethyl ketones as inhibitors of ...
Knez Damijan, Proj Matic, Bozovičar Krištof, Gobec Stanislav   +3 more
doaj   +1 more source

Synthesis of α-Heterosubstituted Ketones Through Sulfur Mediated Difunctionalization of Internal Alkynes

, 2019
Synthesis of α-heterosubstituted ketones was achieved through sulfur mediated difunctionalization of internal alkynes in one-pot. The reaction design involves: phenyl substituted internal alkyne attacking the triflic anhydride activated diphenyl ...
Hongguang, Du, Jiaxi, Xu, Zhong, Zhang, Pingfan, Li   +3 more
core   +1 more source

Organocatalytic Michael addition–lactonisation of carboxylic acids using α,β-unsaturated trichloromethyl ketones as α,β-unsaturated ester equivalents

, 2014
The authors thank the Royal Society for a University Research Fellowship (ADS), The Carnegie Trust for the Universities of Scotland (LCM), Syngenta/EPSRC (Case award to DGS), GSK/EPSRC (CASE award to SRS), the EU (IEF for CS), and the European Research ...
Morrill, L.C., D'Hollander, A.C.A., O'Riordan, Timothy J. C., O'Riordan, T.J.C., Taylor, James E., Shapland, Peter, Smith, S.R., Morrill, Louis, Shapland, P., Stark, Daniel G., Smith, Siobhan R., Simal Fernandez, Carmen, D'Hollander, Agathe C. A., Stark, D.G., Smith, A.D., Taylor, J.E., Squires, James A., Squires, J.A., Smith, Andrew D., Simal, Carmen   +19 more
core   +1 more source

Oxidative Cleavage of Ketoximes to Ketones using Photoexcited Nitroarenes

, 2023
Methoximes are a versatile directing group for a variety of C–H functionalizations. Despite their importance as a powerful functional handle, their conversion to the parent ketone, which is often desired, usually requires harsh and functional group ...
Richmond, Sarpong, Stefan , Wiesler, Lucas, Göttemann   +2 more
core   +1 more source

Base- and Co(II)-Catalyzed Ring-Opening Reactions of Perhydrooxireno[2,3-d][1,2]dioxines:  An Efficient Route to 4-Hydroxy-2,3-epoxy-ketones

, 2016
A series of 3,4,6-substituted 3,6-dihydro-1,2-dioxines were epoxidized with m-chloroperbenzoic acid to furnish perhydrooxireno[2,3-d][1,2]dioxines (epoxy-1,2-dioxines) in yields ranging from 51% to 93% with de's from 26% to 100%.
Natalie F. Jenkins (3034512), Dennis K. Taylor (1645621), Edward R. T. Tiekink (1550791), Ben W. Greatrex (1795870)   +3 more
core   +1 more source

DFT Mechanistic Insights into the Ni(II)-Catalyzed Enantioselective Arylative Cyclization of Tethered Allene-Ketones

, 2023
Density functional theory (DFT) has provided a detailed mechanistic picture for the redox neutral nickel(II)-catalyzed arylative cyclization reactions of a tethered allene-ketone with arylboronic acids. A mechanistic rationale for the high diastereo- and
Richmond Lee (1771750), Christopher JT Hyland (20253975), Chi Bong Eric Chao (20250666), Stephen G Pyne (20250669)   +3 more
core  

Scientific Opinion on Flavouring Group Evaluation 9, Revision 3 (FGE.09Rev3): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25

EFSA Journal, 2011
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 17 flavouring substances in the Flavouring Group Evaluation 9, Revision 3, using the Procedure in Commission ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source

Effect of increased protein intake and exogenous ketosis on body composition, energy expenditure and exercise capacity during a hypocaloric diet in recreational female athletes

Frontiers in Physiology, 2023
Introduction: Since low body weight is an important determinant of success in many sports such as gymnastics, martial arts and figure skating, athletes can benefit from effective weight loss strategies that preserve muscle mass and athletic performance ...
Charlotte Hiroux, Moniek Schouten, Isabelle de Glisezinski, Isabelle de Glisezinski, Chantal Simon, François Crampes, Peter Hespel, Katrien Koppo   +7 more
doaj   +1 more source

Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

, 2020
Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium in situ followed by a radical-radical coupling was made possible using ...
Karl, Scheidt, keegan, fitzpatrick, Anna, Davies, Rick, Betori   +3 more
core   +1 more source

General and mild Ni0-catalyzed α-arylation of ketones using aryl chlorides

, 2015
The authors thank the ERC (Advanced Researcher award-FUNCAT), 7th Framework Program NMP2-LA-2010-246461 (SYNFLOW), the EPSRC and King Saud University for funding.A general methodology for the α-arylation of ketones using a nickel catalyst has been ...
Slawin, Alexandra MZ, Slawin, Alexandra Martha Zoya, Nolan, Steven Patrick, Cordes, David B, Fernandez-Salas, Jose A, Fernandez Salas, Jose Antonio, Cordes, David Bradford, Nolan, Steven, Marelli, Enrico   +8 more
core   +1 more source