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Transgene Design and Delivery into the Mouse Genome: Keys to Success
2009Mouse transgenesis by pronuclear injection generates random integration events resulting in variable overexpression efficiency. This chapter will outline current strategies for improved transgene design (using plasmids or bacterial artificial chromosomes) and delivery to the mouse genome.
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What Are the Key Targeted Delivery Technologies of siRNA Now?
2010Whilst significant advances have been made in the delivery of nucleic acids to mammalian cells, most of the used strategies do not distinguish between normal and cancer cells. The same challenge is also facing radioactive- and chemo-therapies which are highly toxic and poorly tolerated due to limited tumor specificity.
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Planning for post‐pandemic cancer care delivery: Recovery or opportunity for redesign?
Ca-A Cancer Journal for Clinicians, 2021Kathryn Gold, Hope Rugo, Pelin Cinar
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Shanu Modi +2 more
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Drug delivery to the central nervous system
Nature Reviews Materials, 2021Elizabeth Nance +2 more
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Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
Nature Reviews Drug Discovery, 2023Kevin Mchugh +2 more
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