Results 101 to 110 of about 3,543,901 (295)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Polyvictimization: Children\u27s Exposure to Multiple Types of Violence, Crime, and Abuse. [PDF]

, 2011
Presents the findings of the National Survey of Children\u27s Exposure to Violence (NatSCEV) regarding children\u27s direct exposure to multiple types of violence, crime, and abuse, also known as polyvictimization.
Finkelhor, David, Hamby, Sherry L, Ormrod, Richard, Turner, Heather   +3 more
core   +1 more source

Identity-Based Chameleon Hash Scheme without Key Exposure [PDF]

, 2010
The notion of chameleon hash function without key exposure plays an important role in designing chameleon signatures. However, all of the existing key-exposure free chameleon hash schemes are presented in the setting of certificate-based systems. In 2004, Ateniese and de Medeiros questioned whether there is an efficient construction for identity-based ...
Chen, Xiaofeng, Zhang, Fangguo, Susilo, Willy, Tian, Haibo, Li, Jin, Kim, Kwangjo   +5 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Advances in diagnostic assays for Clostridioides difficile infection in adults

Frontiers in Cellular and Infection Microbiology
Clostridioides difficile (C. difficile) was a gram-positive anaerobic bacterium in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. C.
Dong-ang Liu, Dong-ang Liu, Shiyu Chen, Shiyu Chen, Ruiyao Hu, Ruiyao Hu, Yuting Qiu, Yuting Qiu, Keyi Chen, Keyi Chen, Yue Xu, Yue Xu, Jinghua Yuan, Jinghua Yuan, Xinling Zhang, Xinling Zhang, Xiaoping Li, Xiaoping Li   +17 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

An alcohol-governed mechanism of monocarbonyl oligomerization: implications for explosive growth of fine particulate matter

npj Climate and Atmospheric Science
Secondary organic aerosol (SOA), as a major component of fine particulate matter (PM2.5), significantly impacts air quality, climate, and human health. Although the aqueous chemistry of oxygenated organic compounds (OOCs) is acknowledged as an important ...
Yuemeng Ji, Jiaxin Wang, Yongpeng Ji, Yanpeng Gao, Weina Zhang, Jiangyao Chen, Guiying Li, Taicheng An   +7 more
doaj   +1 more source

Abscisic acid-producing bacterium Azospirillum brasilense effectively reduces heavy metals (cadmium, nickel, lead, and zinc) accumulation in pak choi across various soil types

Ecotoxicology and Environmental Safety
Heavy metal contamination of soil is a serious environmental issue that threatens agricultural products and human health. Previous studies have shown that abscisic acid (ABA)-producing bacteria can effectively decrease heavy metal accumulation in plants.
Ran Wu, Xiaohang Sun, Mengfei Zhu, Ying Wang, Yaxin Zhu, Zhiguo Fang, Huijun Liu, Shaoting Du   +7 more
doaj   +1 more source