Results 81 to 90 of about 3,543,901 (295)

The relationship between mixed exposure to blood metal and serum neurofilament light chain levels in the general U.S. population: an unsupervised clustering approach

Frontiers in Public Health
BackgroundSerum neurofilament light chain (sNfL) has demonstrate significant clinical value in quantifying neuronal injury. Concurrently, extensive evidence has linked metal exposure to neurotoxic effects. However, the potential association between metal
Jiyu Nie, Jiyu Nie, Lin Wen, Zhentian Lai, Zhentian Lai, Chuhang Lin, Chuhang Lin, Haiyin Li, Haiyin Li, Jing Zhang, Jing Zhang, Shen Xie, Shen Xie, Xiaosong Ben, Chunxia Jing, Chunxia Jing   +15 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

SEO Techniques for Business Websites [PDF]

In the world of website marketing, search engines are an essential key to success. They are the most important way to bring traffic to websites. Understanding how search engines work and what they require is an important first step to harnessing their ...
Alexandru ENACEANU
core   +3 more sources

Engineering Bacillus subtilis for high-value bioproduction: recent advances and applications

Microbial Cell Factories
Bacillus subtilis, a key model strain in microbial physiology and biochemistry research, is non-pathogenic, secretes proteins efficiently, and has a clear genetic background, making it an ideal host for producing heterologous proteins, such as small ...
Zi-Yan Liu, Xiao-Zheng Yu
doaj   +1 more source

The association between exposure to polycyclic aromatic hydrocarbons and the risk of premature rupture of membranes

Ecotoxicology and Environmental Safety
Background: Premature rupture of membranes (PROM) remains a significant clinical challenge. It has substantial socioeconomic impacts. Despite the known toxicity of polycyclic aromatic hydrocarbons (PAH), there is limited epidemiological evidence on their
Kui Xie, Haixia Tian, Xinyi Xiao, Linfei Wu, Cheng Chen, Shimin Xiong, Lulu Dai, Xingyan Liu, Rong Zeng, Yan Xie, Yijun Liu, Xubo Shen, Zuqiang Wu, Yuanzhong Zhou   +13 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Association between exposure to terpene compounds and risk of metabolic syndrome: exploring the potential mediating role of inflammatory response

Frontiers in Endocrinology
BackgroundTerpenes are potentially harmful substances that are associated with endocrine disruption due to their ability to produce oxidizers, aldehydes, and secondary aerosol particles.
Jiyu Nie, Jiyu Nie, Zhizhuo Huang, Zhizhuo Huang, Lin Wen, Lin Wen, Lin Wen, Haiying Li, Haiying Li, Qianqian Xie, Qianqian Xie, Houchun Wang, Zhengtian Lai, Zhengtian Lai, Chuhang Lin, Chuhang Lin, Chunxia Jing, Chunxia Jing   +17 more
doaj   +1 more source

Role of antioxidant supplementation and exercise regimen in handling oxidative stress from natural PM2.5 exposure due to boreal forest fire [PDF]

, 2019
Thesis (M.S.) University of Alaska Fairbanks, 2019Particulate matter 2.5 (PM2.5) exposure induces oxidative stress that causes many negative health outcomes such as cancer, cardiovascular disease and neurodegenerative disease. Research shows that dietary
Witkop, Jacob J.
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source