Results 81 to 90 of about 1,515,339 (267)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

An alcohol-governed mechanism of monocarbonyl oligomerization: implications for explosive growth of fine particulate matter

npj Climate and Atmospheric Science
Secondary organic aerosol (SOA), as a major component of fine particulate matter (PM2.5), significantly impacts air quality, climate, and human health. Although the aqueous chemistry of oxygenated organic compounds (OOCs) is acknowledged as an important ...
Yuemeng Ji, Jiaxin Wang, Yongpeng Ji, Yanpeng Gao, Weina Zhang, Jiangyao Chen, Guiying Li, Taicheng An   +7 more
doaj   +1 more source

Abscisic acid-producing bacterium Azospirillum brasilense effectively reduces heavy metals (cadmium, nickel, lead, and zinc) accumulation in pak choi across various soil types

Ecotoxicology and Environmental Safety
Heavy metal contamination of soil is a serious environmental issue that threatens agricultural products and human health. Previous studies have shown that abscisic acid (ABA)-producing bacteria can effectively decrease heavy metal accumulation in plants.
Ran Wu, Xiaohang Sun, Mengfei Zhu, Ying Wang, Yaxin Zhu, Zhiguo Fang, Huijun Liu, Shaoting Du   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Aqueous-Phase Reaction Mechanisms of Small α-Dicarbonyls in the Presence of Phthalate Esters

Toxics
Oligomerization of glyoxal (GL) and methylglyoxal (MG) plays a vital role in secondary organic aerosol (SOA) formation in aqueous aerosols. However, the influence of emerging contaminants on the oligomerization of GL and MG remains unclear.
Wenjian Li, Qiuju Shi, Jiaxin Wang, Ruize Ma, Yanpeng Gao, Yuemeng Ji   +5 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stereoselective toxicity and metabolic impacts of difenoconazole-alcohol enantiomers in earthworms: Accumulation, degradation, and oxidative stress

Ecotoxicology and Environmental Safety
The stereoselective effects of difenoconazole-alcohol on soil organisms have not been extensively studied. This research investigates the accumulation, degradation, and oxidative stress induced by difenoconazole-alcohol and its enantiomers in earthworms ...
Huizhen Wu, Jiyang Zhuang, Siyi Chai, Yujia Guo, Guangyi Xu, Likun Wang, Jun Xia, Zhexiong Jin, Mingrong Qian   +8 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source