Results 61 to 70 of about 1,515,339 (267)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Engineering Bacillus subtilis for high-value bioproduction: recent advances and applications

Microbial Cell Factories
Bacillus subtilis, a key model strain in microbial physiology and biochemistry research, is non-pathogenic, secretes proteins efficiently, and has a clear genetic background, making it an ideal host for producing heterologous proteins, such as small ...
Zi-Yan Liu, Xiao-Zheng Yu
doaj   +1 more source

The relationship between mixed exposure to blood metal and serum neurofilament light chain levels in the general U.S. population: an unsupervised clustering approach

Frontiers in Public Health
BackgroundSerum neurofilament light chain (sNfL) has demonstrate significant clinical value in quantifying neuronal injury. Concurrently, extensive evidence has linked metal exposure to neurotoxic effects. However, the potential association between metal
Jiyu Nie, Jiyu Nie, Lin Wen, Zhentian Lai, Zhentian Lai, Chuhang Lin, Chuhang Lin, Haiyin Li, Haiyin Li, Jing Zhang, Jing Zhang, Shen Xie, Shen Xie, Xiaosong Ben, Chunxia Jing, Chunxia Jing   +15 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Aging Process of Sea Salt Particles Driven by Glyoxal: Implications for Climate Effects

Toxics
Atmospheric sea spray aerosol (SSA) undergoes chemical aging during long-distance transport, leading to significant alterations in its climate effects.
Yongpeng Ji, Zhiming Zhang, Shengping Chen, Qiuju Shi, Jiaxin Wang, Baocong Zhao, Weina Zhang, Jiangyao Chen, Yuemeng Ji   +8 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The association between exposure to polycyclic aromatic hydrocarbons and the risk of premature rupture of membranes

Ecotoxicology and Environmental Safety
Background: Premature rupture of membranes (PROM) remains a significant clinical challenge. It has substantial socioeconomic impacts. Despite the known toxicity of polycyclic aromatic hydrocarbons (PAH), there is limited epidemiological evidence on their
Kui Xie, Haixia Tian, Xinyi Xiao, Linfei Wu, Cheng Chen, Shimin Xiong, Lulu Dai, Xingyan Liu, Rong Zeng, Yan Xie, Yijun Liu, Xubo Shen, Zuqiang Wu, Yuanzhong Zhou   +13 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Association between exposure to terpene compounds and risk of metabolic syndrome: exploring the potential mediating role of inflammatory response

Frontiers in Endocrinology
BackgroundTerpenes are potentially harmful substances that are associated with endocrine disruption due to their ability to produce oxidizers, aldehydes, and secondary aerosol particles.
Jiyu Nie, Jiyu Nie, Zhizhuo Huang, Zhizhuo Huang, Lin Wen, Lin Wen, Lin Wen, Haiying Li, Haiying Li, Qianqian Xie, Qianqian Xie, Houchun Wang, Zhengtian Lai, Zhengtian Lai, Chuhang Lin, Chuhang Lin, Chunxia Jing, Chunxia Jing   +17 more
doaj   +1 more source