Results 51 to 60 of about 6,742,422 (376)
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
General Design Layout of Datengxia Ship Lock
Renmin Zhujiang, 2022 The Datengxia hydro project is a key project to open the 100-million-ton golden waterway of the Xijiang River,with high navigation requirements for the dam-site reach and a huge freight volume.The general design layout of the navigation structure ship ...
LI Yawen, CHEN Guihua
doaj
Química Nova, 2005 In general, molecular modeling techniques applied in medicinal chemistry have been static and drug based. However the active site geometry and the intrinsic flexibility of both receptor and ligand are fundamental properties for molecular recognition and ...
Hugo Verli, Eliezer J. Barreiro
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
A comparison between internal protein nanoenvironments of α-helices and β-sheets.
PLoS ONE, 2020 Secondary structure elements are generally found in almost all protein structures revealed so far. In general, there are more β-sheets than α helices found inside the protein structures.
Ivan Mazoni +4 more
doaj +1 more source
, 2002 Quantitative predictions are presented of a depletion-induced torque and force acting on a single colloidal hard rod immersed in a solvent of hard spheres close to a planar hard wall. This torque and force, which are entirely of entropic origin, may play
A. Vrij +16 more
core +2 more sources
Key-lock pair mechanism for access control using tribes of Farey fractions. [PDF]
, 2000 We propose a new single key-lock mechanism based on the concept of an access control matrix. In this system, each file is given a lock and each user is given a key and through simple operations on keys and locks the user access privilege can be revealed.
Chandrashekhar, H., Nagaraj, M.
core +1 more source
Chemical Science, 2019 Using a highly specific “lock and key” fluorescent Cys probe, we confirmed that targeting Cys metabolism to deplete intracellular Cys is a more potent strategy to sensitize cancer cells to chemotherapies.
Jing Liu +6 more
semanticscholar +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
“Lock ‘Em Up . . .” but Where’s the Key? Transformative Drama with Incarcerated Youth
Journal of Contemporary Issues in Education, 2014 A research study doing applied theatre with youth at an Alberta, Canada young offender facility, asks: How can participatory drama contribute to the education of incarcerated youth to avoid future negative outcomes of their “at-risk” behaviours?
Diane Conrad
doaj +1 more source