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The intrinsically disorderly story of Ki-67 [PDF]
Open Biology, 2021 Ki-67 is one of the most famous marker proteins used by histologists to identify proliferating cells. Indeed, over 30 000 articles referring to Ki-67 are listed on PubMed. Here, we review some of the current literature regarding the protein.
Lucy Remnant +4 more
doaj +5 more sources
Cell Death & Differentiation, 2021 Ki-67 serves as a prominent cancer marker. We describe how expression of the MKI67 gene coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are maximally expressed in G2 phase and mitosis. Expression is dependent on two CHR
S. Uxa +5 more
semanticscholar +3 more sources
Ki-67: more than a proliferation marker [PDF]
Chromosoma, 2018 Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and its cellular distribution dramatically changes during cell cycle progression.
Xiaoming Sun, P. Kaufman
semanticscholar +3 more sources
Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors
European Journal of Breast Health, 2019 Objective:The clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. The aim of study is to find the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and ...
Gül Kanyılmaz +5 more
doaj +2 more sources
Revisiting Ki-67 Assessment in Canine Mast Cell Tumours: From Manual Hotspot to Automated Global Analysis [PDF]
Veterinary SciencesCanine mast cell tumours (MCTs) show highly variable behaviour, and Ki-67 is an established prognostic indicator. Conventional Ki-67 assessment is manual and restricted to small hotspot areas, limiting reliability.
Rebeca Scalco +5 more
doaj +2 more sources
Imaging characteristics of central neurocytomas according to Ki-67 proliferation index [PDF]
Frontiers in OncologyPurposeTo evaluate the imaging characteristics of central neurocytoma (CN) with different Ki-67 indices and reveal its biological behavior.Materials and methodsSixty-nine cases of intraventricular CN confirmed by histopathology were collected ...
Yan-li Zhang +4 more
doaj +2 more sources
The association between Ki-67 expression and survival in breast cancer subtypes: a cross-sectional study of Ki-67 cut-point in northern Thailand [PDF]
BMC CancerBackground Breast cancer is a major health concern worldwide, and Ki-67 level index is a prognostic factor that indicates tumor proliferation and predicts survival outcomes. However, the standard Ki 67 cut-off level varies between local laboratories, and
Phanchaporn Wongmaneerung +9 more
doaj +2 more sources
Association between Ki-67 and clinical outcomes in 324 Chinese patients with resectable acral melanoma [PDF]
Scientific ReportsThe relationship between Ki-67 expression and clinical prognosis in patients with resectable acral melanoma (AM) remains unclear. This study explores the prognostic role of Ki-67 in AM using data from 324 patients across five Chinese centers.
Yi Teng +14 more
doaj +2 more sources
Annals of Oncology, 2021 BACKGROUND Adjuvant abemaciclib combined with endocrine therapy (ET) previously demonstrated clinically meaningful improvement in invasive disease-free survival (IDFS) and distant relapse-free survival (DRFS) in HR+, HER2-, node-positive, high risk early
N. Harbeck +34 more
semanticscholar +1 more source
Cancers, 2023 Simple Summary Cellular proliferation is a central determinant of breast cancer recurrence risk and response to chemotherapy. The discovery of the Ki-67 antibody by Dr.
B. Finkelman +3 more
semanticscholar +1 more source