Brain Sciences, 2022 Objective: The Ki-67 index is an indicator of the active proliferation and aggressive behavior of pituitary adenomas (PAs). Appropriate pre- and intra-operatives of the Ki-67 index can help surgeons develop better and more personalized treatment ...
Xuanzhi Wang +5 more
doaj +1 more source
The time-dependent localization of Ki 67 antigen-positive cells in human skin wounds [PDF]
, 1993 A total of 77 human skin wounds with a post-infliction interval between 3 h and 7 months were investigated and the proliferation marker antigen Ki 67 was visualized in paraffin sections using a specific monoclonal antibody (MIB).
A. Nerlich +22 more
core +1 more source
Ki-67 expression in pulmonary tumors—reply [PDF]
Translational Lung Cancer Research, 2016 First of all, we would like to congratulate Professor Chirieac for his excellent discussion on proliferation assessment in lung tumors. Taken together, he concludes that assessment of proliferation is important for the prognosis of non-small cell lung cancer (NSCLC), prediction of brain metastases in patients with lung adenocarcinoma, and the diagnosis,
Mark, Kriegsmann, Arne, Warth
openaire +2 more sources
Effects of Imipramine and Lithium on the Suppression of Cell Proliferation in the Dentate Gyrus of the Hippocampus in Adrenocorticotropic Hormone-treated Rats [PDF]
, 2010 We examined the influence of chronic adrenocorticotropic hormone (ACTH) treatment on the number of Ki-67-positive cells in the dentate gyrus of the hippocampus in rats. ACTH treatment for 14 days decreased the number of such cells.
Asanuma, Masato +9 more
core +1 more source
Differentiation-dependent glycosylation of cells in squamous cell epithelia detected by a mammalian lectin [PDF]
, 2002 The squamous stratified epithelia contain a proliferative (harboring mitotic activity) and a differentiating compartment. Due to the potential of protein-carbohyd rate interactions to regulate cellular activities we introduced a mammalian lectin to cyto-
Dvorankova, Barbora +7 more
core +1 more source
RUDN Journal of Medicine, 2019 Prostate cancer is one of the leading causes of men death in developed countries. Modern diagnostic methods, including a puncture biopsy of the prostate gland, make it possible to verify oncology in the early stages, however, routine studies do not ...
G. Y. Kudryavtsev +3 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Localisation of the Ki-67 antigen within the nucleolus: Evidence for a fibrillarin-deficient region of the dense fibrillar component [PDF]
, 1996 The Ki-67 antigen is detected in proliferating cells in all phases of the cell division cycle. Throughout most of interphase, the Ki-67 antigen is localised within the nucleolus.
Kill, IR
core
DNA ploidy and cell cycle protein expression in oral squamous cell carcinomas with and without lymph node metastases [PDF]
, 2017 Background: Oral squamous cell carcinoma (OSCC) is the most frequently occurring malignant tumour in the oral cavity. OSCC arises because of multiple genetic alterations. Cell cycle aberrations and aneuploidy are reportedly among the main characteristics
Abou-Elhamd +29 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source