Results 111 to 120 of about 203,911 (336)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

EXPRESSION OF P16 MUTANT PROTEIN AND KI67 IN CUTANEOUS AND NON-CUTANEOUS MELANOMA

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine expression of p16 mutant protein and ki67 in cutaneous and non-cutaneous melanoma. Study Design: Cross sectional study. Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from July 2017 to July ...
Farhan Akhtar, Mohammad Hassan, Mohammad Ali, Rabia Ahmed, Muhammad Asif, Ghazala Sadaf, Muhammad Tahir Khadim   +6 more
doaj  

The zinc finger transcription factor PW1/PEG3 restrains murine beta cell cycling [PDF]

, 2016
Aims/hypothesis: Pw1 or paternally-expressed gene 3 (Peg3) encodes a zinc finger transcription factor that is widely expressed during mouse embryonic development and later restricted to multiple somatic stem cell lineages in the adult.
Besson, Vanessa, Bonfanti, Paola, Heimberg, Harry, Heremans, Yves, Leuckx, Gunter, Marazzi, Giovanna, Sassoon, David, Sojoodi, Mozhdeh, Staels, Willem, Stradiot, Leslie, Tanaka, Karo, Van de Casteele, Mark   +11 more
core   +3 more sources

Ki67 labeling in CNS tumours

Indian Journal of Pathology and Oncology, 2019
A study of Ki67 Labeling Index (LI) by immunohistochemistry was carried out in 47 CNS neoplasms. Astrocytic and oligodendroglial tumours were the most common group with glioblastoma, NOS and diffuse astrocytoma, NOS Grade II predominating. Ki67 LI of diffuse astrocytomas varied from 0.72 to 13.9% with a mean of 4.36%.
Uttara Mani, Manjiri Karandikar, Narayanan Subramanian Mani   +2 more
openaire   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

Advanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, Min‐Goo Lee, Qian‐Yong Cao, Jong Seung Kim   +10 more
wiley   +1 more source

Correlations Between Oncotype DX Recurrence Score and Classic Risk Factors in Early Breast Cancer: Results of A Prospective Multicenter Study in Turkey

European Journal of Breast Health, 2016
Objective: Breast cancer is the most common malignancy among Turkish women and the rate of early stage disease is increasing. The Oncotype DX 21-gene assay is predictive of distant recurrence in ER-positive, HER2-negative early breast cancer. We aimed to
Vahit Özmen, Ajlan Atasoy, Erhan Gökmen, Mustafa Özdoğan, Nilufer Güler, Cihan Uras, Engin Ok, Orhan Demircan, Abdurrahman Işıkkdoğan, Neslihan Cabioğlu, Fatma Şen, Pınar Saip   +11 more
doaj   +1 more source

Modeling CD4+ T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7 [PDF]

, 2016
Combination Antiretroviral Therapy (cART) succeeds to control viral replication in most HIV infected patients. This is normally followed by a reconstitution of the CD4$^+$ T cells pool; however, this does not happen for a substantial proportion of ...
Commenges, Daniel, Jarne, Ana, Levy, Yves, Prague, Mélanie, Thiébaut, Rodolphe   +4 more
core   +2 more sources

Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastoma. [PDF]

, 2015
Medulloblastoma (MB) is a highly malignant brain tumor that occurs primarily in children. Although surgery, radiation and high-dose chemotherapy have led to increased survival, many MB patients still die from their disease, and patients who survive ...
Berezov, A, Brun, SN, Conway, EM, Crawford, JR, Esparza, LA, Garcia, G, Grant, GA, Greene, MI, Huang, J-M, Levy, ML, Li, X-N, Markant, SL, Nakano, I, Pavlyukov, MS, Smith, LH, Terry, D, Wang, Q, Wechsler-Reya, RJ   +17 more
core   +2 more sources

Correlation between Ki67 and Breast Cancer Prognosis

Oncology, 2013
<b><i>Background:</i></b> Ki67 is an immunohistochemical proliferation marker in many types of cancer and has been widely studied among breast cancer patients mostly through retrospective studies. <b><i>Methods:</i></b> The MEDLINE/PubMed database was searched for publications with the medical subject ...
Kontzoglou, K., Palla, V., Karaolanis, G., Karaiskos, I., Alexiou, I., Pateras, I., Konstantoudakis, K., Stamatakos, M.   +7 more
openaire   +3 more sources

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source