Results 71 to 80 of about 203,911 (336)

The small molecule ephrin receptor inhibitor, GLPG1790, Reduces renewal capabilities of cancer stem cells, showing anti-tumour efficacy on preclinical glioblastoma models [PDF]

, 2019
Therapies against glioblastoma (GBM) show a high percentage of failure associated with the survival of glioma stem cells (GSCs) that repopulate treated tumours.
Beirinckx, Filip, Colapietro, Alessandro, Cristiano, Loredana, Delle Monache, Simona, Festuccia, Claudio, Gravina, Giovanni, Lorenzon, Giocondo, Mancini, Andrea, Marampon, Francesco, Martellucci, Stefano, Mattei, Vincenzo, Pujuguet, Philippe, Saniere, Laurent, Sferra, Roberta, van der Aar, Ellen, Vitale, Flora   +15 more
core   +2 more sources

Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance)

Journal of Clinical Oncology, 2017
Purpose To determine the pathologic complete response (pCR) rate in estrogen receptor (ER) –positive primary breast cancer triaged to chemotherapy when the protein encoded by the MKI67 gene (Ki67) level was > 10% after 2 to 4 weeks of neoadjuvant ...
M. Ellis, V. Suman, J. Hoog, R. Gonçalves, Souzan Sanati, C. Creighton, K. Deschryver, E. Crouch, A. Brink, Mark Watson, Jingqin R Luo, Y. Tao, Michael Barnes, M. Dowsett, G. Budd, E. Winer, P. Silverman, L. Esserman, L. Carey, Cynthia X. Ma, G. Unzeitig, T. Pluard, P. Whitworth, G. Babiera, J. Guenther, Z. Dayao, D. Ota, M. Leitch, J. Olson, D. Allred, K. Hunt   +30 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Antibodies and anti-antibodies specific to estradiol and progesterone and tumor proliferation in breast cancer patients

Сибирский онкологический журнал
The study was aimed to determine the interrelations between levels of serum antibodies specific to estradiol and progesterone (IgA1-E2 and IgA1-Pg) and corresponding antiidiotypic antibodies (IgG2-E2 and IgG2-Pg) and tumor Ki67 positive cells in breast ...
A. N. Glushkov, E. G. Polenok, L. A. Gordeeva, P. V. Bayramov, N. E. Verzhbitskaya, A. V. Antonov, G. I. Kolpinsky, M. V. Kostyanko   +7 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Plasmablastic lymphoma in immunocompetent and in immunocompromised patients: Experience at a regional cancer centre in India

South Asian Journal of Cancer, 2017
Introduction: Plasmablastic lymphoma (PBL) is a rare lymphoma associated with immunosuppression. It is strongly associated with immunosuppression (human immunodeficiency virus [HIV]) and often occurs within the oral cavity.
A H Rudresha, K C Lakshmaiah, Ankit Agarwal, K Govind Babu, D Loknatha, Linu Abraham Jacob, Suresh Babu, K N Lokesh, L K Rajeev   +8 more
doaj   +1 more source

Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]

, 2016
Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James, Arias, Angelo, Cates, Charles, Cayanan, Geraldine, Fung, Jennifer, Greene, Lloyd, Karpel-Massler, Georg, Lamé, Michael, Nakayama Wong, Lynn, Rowland, Douglas, Sidorov, Maxim, Siegelin, Markus   +11 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Role of Endoscopic Ultrasound-Guided Ki67 in the Management of Non-Functioning Pancreatic Neuroendocrine Tumors [PDF]

Clinical Endoscopy, 2020
Background/Aims The management of small, incidentally discovered nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) has been a matter of debate.
YongYan Cui, Lauren G. Khanna, Anjali Saqi, John P. Crapanzano, James M. Mitchell, Amrita Sethi, Tamas A. Gonda, Michael D. Kluger, Beth A. Schrope, John Allendorf, John A. Chabot, John M. Poneros   +11 more
doaj   +1 more source

MiR-205-5p inhibition by locked nucleic acids impairs metastatic potential of breast cancer cells [PDF]

, 2018
Mir-205 plays an important role in epithelial biogenesis and in mammary gland development but its role in cancer still remains controversial depending on the specific cellular context and target genes.
De Cola A., De Laurenzi V., Iezzi M., Lamolinara A., Lanuti P., Marchisio M., Rossi C., Todaro M.   +7 more
core   +1 more source