Results 61 to 70 of about 119,779 (263)

Prognostic Significance of Bcl-2 and p53 Protein Expressions and Ki67 Proliferative Index in Diffuse Large B-cell Lymphoma

Turkish Journal of Hematology, 2013
Objective: Diffuse large B-cell lymphoma (DLBCL) is a high-grade neoplasm that has heterogeneous properties in clinical, morphological, and immunophenotypic aspects.
Betül Bolat Küçükzeybek, Sadi Bener, Aylin Orgen Çallı, Tuğba Doğruluk Paksoy, Bahriye Payzin   +4 more
doaj   +1 more source

The Ki67 dilemma: investigating prognostic cut-offs and reproducibility for automated Ki67 scoring in breast cancer

Breast Cancer Research and Treatment
Abstract Purpose Quantification of Ki67 in breast cancer is a well-established prognostic and predictive marker, but inter-laboratory variability has hampered its clinical usefulness. This study compares the prognostic value and reproducibility of Ki67 scoring using four ...
Emma Rewcastle, Ivar Skaland, Einar Gudlaugsson, Silja Kavlie Fykse, Jan P. A. Baak, Emiel A. M. Janssen   +5 more
openaire   +2 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Clinical and morphological characteristics of wound healing in diabetic foot syndrome

Сахарный диабет, 2017
Aim. To assess the clinical and morphological characteristics of neuropathic diabetic foot ulcers (DFUn) Materials and Methods. Forty-three specimens of DFUn were analysed.
Elena Yur'evna Komelyagina, Eugenia Alexandrovna Kogan, Mikhail Borisovich Antsiferov   +2 more
doaj   +1 more source

Proliferating trichilemmal cyst: The value of ki67 immunostaining

International Journal of Trichology, 2013
A proliferating trichilemmal cyst (PTC) is an uncommon, rapidly-reproducing cutaneous epithelial cyst, differentiating from the isthmic portion of the outer hair root sheath. It is usually described as a benign tumor, but malignant transformation has been reported and is then denominated as a malignant proliferating trichilemmal tumor.
Rangel-Gamboa, Lucia, Reyes-Castro, Magdalena, Dominguez-Cherit, Judith, Vega-Memije, Elisa   +3 more
openaire   +3 more sources

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Analysis of Baseline Serum Lipid Profile for Predicting Clinical Outcomes of Patients with Extensive-Stage Small Cell Lung Cancer

Cancer Management and Research, 2023
Mingshuang Wu,1 Yi He,1 Chenxi Pan2 1Department of Urology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 2Department of Breast Surgery, The Second Affiliated Hospital of Dalian Medical ...
Wu M, He Y, Pan C
doaj  

LARGE UTERINE LEIOMYOMAS: PATHOGENETIC MECHANISMS OF GROWTH

Клиническая практика, 2016
The pathogenesis of uterine fibroids remains controversial and raises many questions. The causes and mechanism of development of large leiomyoma are unknown.
E A Kogan, S I Askolskaya, Yu V Popov, M A Solomakhina, N M Fayzullina   +4 more
doaj   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Establishment and validation of glioma patient-derived organoid models

Glioma
Background and Aim: Glioma is one of the most prevalent and refractory brain cancers with a high recurrence rate. Current limitations of experimental in vitro models include their inability to remodel the heterogeneity of the parental tumors and their ...
Anqi Wang, Xiangtong Xie, Lu Hao, Xuetao Li, Yulun Huang, Zhimin Wang   +5 more
doaj   +1 more source