Results 41 to 50 of about 146,439 (308)

The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients

Radiology and Oncology, 2016
Neuroendocrine markers, which could indicate for aggressive variants of prostate cancer and Ki67 (a well-known marker in oncology for defining tumor proliferation), have already been associated with clinical outcome in prostate cancer.
Pascale Mariarosa, Aversa Cinzia, Barbazza Renzo, Marongiu Barbara, Siracusano Salvatore, Stoffel Flavio, Sulfaro Sando, Roggero Enrico, Bonin Serena, Stanta Giorgio   +9 more
doaj   +1 more source

Ki67 staining on PC3 xenograft specimens.

, 2015
Xenograft tissues of mice (Group 1: untreated control and Group 4: BPA-mediated BNCT) were stained with Ki67, SMa-actin, and DAPI (A:DAPI B:Ki67 C:SMa-actin D:Mixed). Quantification of Ki67-positive cells was shown.
Yuki Yoshikawa (790631), Haruhito Azuma (56385), Teruo Inamoto (56430), Hajime Hirano (790634), Shinji Kawabata (790636), Mitsunori Kirihata (790640), Kiyoshi Takahara (790629), Toshihiko Kuroiwa (790639), Koichiro Minami (790630), Hayahito Nomi (790635), Shin-Ichi Miyatake (790638), Tomoaki Takai (790632), Naokazu Ibuki (790633), Satoshi Kiyama (790637), Minoru Suzuki (337093)   +14 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Human breast milk stem cells: a new challenge for perinatologists

Journal of Pediatric and Neonatal Individualized Medicine, 2016
The lactating mammary gland contains a stem cells population with multilineage potentialities. Recently it was also shown that breast milk contains a heterogeneous population of stem cells that have the potential to differentiate in vitro, under the ...
Giuseppina Pichiri, Daniele Lanzano, Monica Piras, Angelica Dessì, Alessandra Reali, Melania Puddu, Antonio Noto, Vassilios Fanos, Carlo Coni, Gavino Faa, Pierpaolo Coni   +10 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Immunohistochemical Changes of Polycystic Ovaries in rats Treated with Asparagus Officinalis L. Roots Extract

Medical Journal of Babylon
Background:Polycystic ovary syndrome (PCOS) which a series reproductive, metabolic and psychological condition that is characterized by abnormal gonadotropin secretion or hyperandrogenism and associated with insulin resistance and most commonly found in ...
Farah Jawad Al-masoudi, Ashwaq Kadhem Obeid   +1 more
doaj   +1 more source

Ki67 immunostaining.

, 2016
(A)Ki67 immunostaining. A Ki67 positive chondrocyte is indicated (arrow). Scale bars, 100 μm. (B)The Ki67 positive cells were counted. (* indicates the comparison between the compressive stress groups and the control group, * pFig 5A and 5B).
Sheng Chen (21971), Huang Li (823114), Yuanyuan Jiang (349012), Caixia Zhang (467983), Juan Wen (173034)   +4 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Ki67 staining 8 weeks post-OVX.

, 2019
(A-F) DAPI/Ki67 staining. (B-C and E-F) are magnified images of (A& D) respectively. Enumeration of Ki67+ cells in (G) cortical bone and (H) bone marrow.
Priyatha Premnath (4583950), Steven Boyd (4583962), Roman Krawetz (4583956), Leah Ferrie (6577730), Dante Louie (4583953)   +4 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source