Results 41 to 50 of about 119,779 (263)

Human breast milk stem cells: a new challenge for perinatologists

Journal of Pediatric and Neonatal Individualized Medicine, 2016
The lactating mammary gland contains a stem cells population with multilineage potentialities. Recently it was also shown that breast milk contains a heterogeneous population of stem cells that have the potential to differentiate in vitro, under the ...
Giuseppina Pichiri, Daniele Lanzano, Monica Piras, Angelica Dessì, Alessandra Reali, Melania Puddu, Antonio Noto, Vassilios Fanos, Carlo Coni, Gavino Faa, Pierpaolo Coni   +10 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Immunohistochemical Changes of Polycystic Ovaries in rats Treated with Asparagus Officinalis L. Roots Extract

Medical Journal of Babylon
Background:Polycystic ovary syndrome (PCOS) which a series reproductive, metabolic and psychological condition that is characterized by abnormal gonadotropin secretion or hyperandrogenism and associated with insulin resistance and most commonly found in ...
Farah Jawad Al-masoudi, Ashwaq Kadhem Obeid   +1 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Evaluation of P57, P53 and Ki67 Expression in Meningiomas

Journal of Korean Neurosurgical Society, 2022
Objective : We conducted this study with the aim of predicting the biological behavior of meningiomas, and determining the benefits of associating histological subtype and grade with the expression of proliferative markers and tumor suppressor proteins.Methods : The study included 29 patients with primary intracranial and intraspinal meningioma ...
İlknur Küçükosmanoğlu, Meryem İlkay Eren Karanis, Yaşar Ünlü, İlker Çöven   +3 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Non-Small Cell Lung Cancer in Young Patients: An Analysis of Clinical, Pathologic and TNM Stage Characteristics Compared to the Elderly

Risk Management and Healthcare Policy, 2020
Xin Jin, Xin Zhao, Xingsheng Liu, Ke Han, Gaojun Lu, Yi Zhang Thoracic Surgery Department, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yi ZhangThoracic Surgery Department, Xuanwu Hospital, Capital
Jin X, Zhao X, Liu X, Han K, Lu G, Zhang Y   +5 more
doaj  

Effects of propolis on histopathological and immunohistochemical alterations in testes of thyroidectomized rat. [PDF]

Journal of Bioscience and Applied Research, 2016
The thyroid hormones, triiodothyronine (T3) and its prohormone, thyroxine, are secreted by the thyroid gland which are responsible for the regulation of metabolism in all body tissues.
Ezar Hafez
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Immunoexpression of Ki67, p53 and cyclin D1 in osteosarcomas

Romanian Journal of Morphology and Embryology, 2021
The main malignant tumor of the bone tissue is represented by osteosarcoma, neoplasia with a reserved prognosis and an unpredictable evolution, often aggressive. Cell cycle disruption is one of the complex biomolecular mechanisms involved in the progression of osteosarcomas. In this study, we analyzed the immunoexpression of Ki67, p53 and cyclin D1 for
Niculescu, Ştefan Adrian, Grecu, Dan Cristian, Simionescu, Cristiana Eugenia, Niculescu, Elena Carmen, Stepan, Mioara Desdemona, Stepan, Alex Emilian   +5 more
openaire   +2 more sources