Results 21 to 30 of about 123,308 (219)

Recurrence and mortality rate in an Italian multi-center case series of parathyroid atypical adenomas and carcinomas

Frontiers in Endocrinology, 2023
IntroductionThere are few data regarding the clinical outcome of patients with parathyroid carcinoma (PC) and atypical adenoma (AA) after surgery. Aim of our study was to investigate disease recurrence and mortality rate as well as their predictors in a ...
Marco Barale, Alice Nervo, Andrea Craparo, Alessia Pusterla, Francesca Retta, Federica Maiorino, Elena Castellano, Alessandro Piovesan, Laura Gianotti, Giorgio Borretta, Massimo Procopio, Emanuela Arvat   +11 more
doaj   +1 more source

A prognostic prediction model for advanced gastric cancer based on Ki67

Zhongguo linchuang yanjiu
Objective To establish and validate a nomogram model for predicting the prognosis of advanced gastric cancer based on Ki67 expression，and to explore effect of different levels of Ki67 on progression free survival（PFS）in the same patient with different ...
NIU Linjun*，LI Xinzhong，LYU Yongjian
doaj   +1 more source

The Proper Ki-67 Cut-Off in Hormone Responsive Breast Cancer: A Monoinstitutional Analysis with Long-Term Follow-Up

Breast Cancer: Targets and Therapy, 2021
Augusto Lombardi, Rachele Lazzeroni, Laura Bersigotti, Valeria Vitale, Claudio Amanti Department of Breast Surgery, Università di Roma La Sapienza – OspedaleSant’Andrea, Rome, ItalyCorrespondence: Laura BersigottiOspedaleSant&rsquo ...
Lombardi A, Lazzeroni R, Bersigotti L, Vitale V, Amanti C   +4 more
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients

Radiology and Oncology, 2016
Neuroendocrine markers, which could indicate for aggressive variants of prostate cancer and Ki67 (a well-known marker in oncology for defining tumor proliferation), have already been associated with clinical outcome in prostate cancer.
Pascale Mariarosa, Aversa Cinzia, Barbazza Renzo, Marongiu Barbara, Siracusano Salvatore, Stoffel Flavio, Sulfaro Sando, Roggero Enrico, Bonin Serena, Stanta Giorgio   +9 more
doaj   +1 more source

An Ethanolic Extract of Cucurbita pepo L. Seeds Modifies Neuroendocrine Disruption in Chronic Stressed Rats and Adrenal Expression of Inflammatory Markers and HSP70

Frontiers in Pharmacology, 2021
Background: Pumpkins (Cucurbita pepo L.) were described to have antioxidant, anti-inflammatory, anti-fatigue, and antidepressant-like effect. The adrenal gland is an important stress-responsive organ that maintains homeostasis during stress.Objectives ...
Hailah M. Almohaimeed, Shereen Hamed, Hanan S. Seleem, Hanan S. Seleem, Ashwaq H. Batawi, Zuhair M. Mohammedsaleh, Maha Jameal Balgoon, Soad S. Ali, Soad S. Ali, Soad Al Jaouni, Soad Al Jaouni, Nasra Ayuob   +11 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Immunohistochemical Changes of Polycystic Ovaries in rats Treated with Asparagus Officinalis L. Roots Extract

Medical Journal of Babylon
Background:Polycystic ovary syndrome (PCOS) which a series reproductive, metabolic and psychological condition that is characterized by abnormal gonadotropin secretion or hyperandrogenism and associated with insulin resistance and most commonly found in ...
Farah Jawad Al-masoudi, Ashwaq Kadhem Obeid   +1 more
doaj   +1 more source