Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]
, 2016 Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D. +8 more
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Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer [PDF]
, 2015 Introduction Aromatase inhibitors (AIs) are a vital component of estrogen receptor positive (ER+) breast cancer treatment. De novo and acquired resistance, however, is common.
A Mackay +65 more
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Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche. [PDF]
, 2017 A major challenge in stem cell differentiation is the availability of bioassays to prove cell types generated in vitro are equivalent to cells in vivo. In the mouse, differentiation of primordial germ cell-like cells (PGCLCs) from pluripotent cells was ...
Chen, Di +13 more
core +2 more sources
Low correlation between Ki67 assessed by qRT-PCR in Oncotype Dx score and Ki67 assessed by Immunohistochemistry [PDF]
Scientific Reports, 2022 AbstractBreast cancers expressing high levels of Ki67 are associated with poor outcomes. Oncotype DX test was designed for ER+/HER2− early-stage breast cancers to help adjuvant chemotherapy decision by providing a Recurrent Score (RS). RS measures the expression of 21 specific genes from tumor tissue, including Ki67.
Selmani, Zohair +16 more
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Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2023 Согласно современным данным, рак шейки матки (РШМ) занимает одно из ведущих мест в структуре злокачественных новообразований у женщин Республики Беларусь и Российской Федерации, а также является четвертым по распространенности видом рака среди женщин во ...
О. В. Шиман +1 more
doaj +1 more source
The role of recombinant epidermal growth factor and serotonin in the stimulation of tumor growth in a SCCHN xenograft model [PDF]
, 2012 One challenge of squamous cell carcinoma of the head and neck (SCCHN) chemotherapy is a small percentage of tumor cells that arrest in the G0 phase of the cell cycle and are thus not affected by chemotherapy. This could be one reason for tumor recurrence
Arnoldner, Christoph +6 more
core +1 more source
Spermatogonial kinetics in humans [PDF]
, 2017 The human spermatogonial compartment is essential for daily production of millions of sperm. Despite this crucial role, the molecular signature, kinetic behavior and regulation of human spermatogonia are poorly understood.
Berloco, Bartolomeo P. +11 more
core +1 more source
Cancer Management and Research, 2021 Peng Jiang, Rui Yuan Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Rui YuanDepartment of Gynecology, The First Affiliated Hospital of Chongqing Medical ...
Jiang P, Yuan R
doaj
Androgen and estrogen receptor expression in the developing human penis and clitoris. [PDF]
, 2020 To better understand how the human fetal penis and clitoris grows and remodels, we undertook an investigation to define active areas of cellular proliferation and programmed cell death spatially and temporally during development of human fetal external ...
Baskin, Laurence +6 more
core
ki67 nuclei detection and ki67-index estimation: a novel automatic approach based on human vision modeling [PDF]
BMC Bioinformatics, 2019 Abstract Background The protein ki67 (pki67) is a marker of tumor aggressiveness, and its expression has been proven to be useful in the prognostic and predictive evaluation of several types of tumors. To numerically quantify the pki67 presence in cancerous tissue areas, pathologists generally analyze histochemical ...
Barricelli B. R. +6 more
openaire +4 more sources