Results 31 to 40 of about 1,036,066 (335)

Differences between physicians in the likelihood of referral and acceptance of elderly patients for dialysis-influence of age and comorbidity [PDF]

, 2007
BACKGROUND: Incidence of dialysis in elderly patients in the Netherlands is low compared to other countries. This study aims to assess the impact of patients' age and comorbidity on the likelihood of referral and acceptance of patients for dialysis and ...
De Jong, P.E., Dijkstra, G.J., Gansevoort, R.T., Huisman, R.M., Reijneveld, S.A., Visser, A.   +5 more
core   +3 more sources

Pan-cancer classifications of tumor histological images using deep learning [PDF]

, 2020
Histopathological images are essential for the diagnosis of cancer type and selection of optimal treatment. However, the current clinical process of manual inspection of images is time consuming and prone to intra- and inter-observer variability. Here we
Caruana, Dennis, Chuang, Jeffrey H., Farahmand, Saman, Foroughi pour, Ali, Namburi, Sandeep, Noorbakhsh, Javad, Rimm, David, Soltanieh-Ha, Mohammad, Zarringhalam, Kourosh   +8 more
core   +1 more source

Fatal Donor-Derived Carbapenem-Resistant Klebsiella pneumoniae Infection in a Combined Kidney-Pancreas Transplantation

Case Reports in Transplantation, 2016
Carbapenem-resistant Klebsiella pneumoniae (CR-KP) infections in solid organ transplant recipients are associated with high morbidity and mortality. We report a case of a fatal donor-derived CR-KP infection in a combined kidney-pancreas transplant. Given
Giovanni Varotti, Ferdinando Dodi, Anna Marchese, Alessia Terulla, Massimo Bertocchi, Iris Fontana   +5 more
doaj   +1 more source

Frequent Mutations of VHL Gene and the Clinical Phenotypes in the Largest Chinese Cohort With Von Hippel–Lindau Disease

Frontiers in Genetics, 2019
Von Hippel–Lindau (VHL) disease is a rare autosomal-dominant inherited tumor syndrome. We aimed to analyze the correlations between frequent VHL mutations and phenotypes in Chinese VHL families.
Baoan Hong, Baoan Hong, Baoan Hong, Baoan Hong, Baoan Hong, Baoan Hong, Kaifang Ma, Kaifang Ma, Kaifang Ma, Kaifang Ma, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Jiangyi Wang, Jiangyi Wang, Jiangyi Wang, Jiangyi Wang, Shengjie Liu, Shengjie Liu, Shengjie Liu, Shengjie Liu, Zhongyuan Zhang, Zhongyuan Zhang, Zhongyuan Zhang, Zhongyuan Zhang, Lin Cai, Lin Cai, Lin Cai, Lin Cai, Ning Zhang, Ning Zhang, Kan Gong, Kan Gong, Kan Gong, Kan Gong   +39 more
doaj   +1 more source

Abnormal liver tests are not sufficient for diagnosis of hepatic graft‐versus‐host disease in critically ill patients

Hepatology Communications, 2022
Hepatic graft‐versus‐host disease (HGVHD) contributes significantly to morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Clinical findings and liver biomarkers are neither sensitive nor specific.
Alexander H. Yang, Mai Ai Thanda Han, Niharika Samala, Bisharah S. Rizvi, Rachel Marchalik, Ohad Etzion, Elizabeth C. Wright, Ruchi Patel, Vinshi Khan, Devika Kapuria, Vikramaditya Samala Venkat, David E. Kleiner, Christopher Koh, Jennifer A. Kanakry, Christopher G. Kanakry, Steven Pavletic, Kirsten M. Williams, Theo Heller   +17 more
doaj   +1 more source

Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]

, 2016
Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran, Anderson, Katie, Berryhill, Grace, Chen, Ching-Hsien, Graef, Ashley, Hovey, Russell C, Kim, Jeffrey, Modiano, Jaime F, Sarver, Aaron L, Stewart, Benjamin, Trott, Josephine F, Uzal, Francisco, Weiss, Robert H, Wettersten, Hiromi   +13 more
core   +2 more sources

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Systematic study of constitutive cyclo-oxygenase-2 expression: role of NFκB and NFAT transcriptional pathways [PDF]

, 2015
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs).
Ahmetaj-Shala, B, Berglund, LM, Chan, MV, Garcia-Vaz, E, Gomez, MF, Herschman, HR, Jiao, J, Kirkby, NS, Mitchell, JA, Verdu, EF, Wallace, JL, Zaiss, AK   +11 more
core   +1 more source

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
core   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source