Results 1 to 10 of about 627,404 (266)
Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis
Frontiers in Pharmacology, 2022 Aim: Peritoneal dialysis is a common renal replacement method for end-stage renal disease. Long-term peritoneal dialysis leads to peritoneal dialysis-related peritoneal fibrosis, which leads to a cessation of treatment.
Fang Li +9 more
doaj +1 more source
Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair
Nature Communications, 2022 G2/M arrest of epithelial cells leads to fibrosis with unclear mechanisms. This study identifies a protein-encoding circRNA, circBNC2, which inhibits epithelial cells G2/M arrest to prevent fibrotic maladaptive repair in damaged kidney and liver ...
Peng Wang +10 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background The association of a healthy lifestyle with the prognosis of type 2 diabetes remains uncertain. We aimed to evaluate the associations of a healthy lifestyle and a higher American Heart Association's Life's Essential 8 score with incident ...
Panpan He +9 more
doaj +1 more source
Cell Death and Disease, 2023 Kidney fibrosis, characterized by the activation and expansion of the matrix-producing fibroblasts, is the common outcome of chronic kidney disease (CKD).
Xi Liu +8 more
doaj +1 more source
Cell Death and Disease, 2021 Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase involved in regulating a wide range of biologic processes, such as apoptosis, cell proliferation, and tissue remodeling.
Chengxiao Hu +9 more
doaj +1 more source
Cell Death and Disease, 2021 Phosphatase and Tensin Homolog on chromosome Ten (PTEN) has emerged as a key protein that governs the response to kidney injury. Notably, renal adaptive repair is important for preventing acute kidney injury (AKI) to chronic kidney disease (CKD ...
Huizhen Wang +6 more
doaj +1 more source
The Lancet Regional Health - Western Pacific, 2020 There is limited literature on kidney disease in the Pacific Region, despite it being recognised as a leading cause of death in some Pacific Island nations. Kidney replacement therapy is only available in a handful of Pacific Islands. This paper reports the epidemiology of haemodialysis patients in Samoa.Registry data from the National Kidney ...
Malama Tafuna'i +7 more
openaire +3 more sources
Diabetology & Metabolic Syndrome, 2022 Background We aimed to investigate the joint effect of visit-to-visit variability (VVV) in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and glycosylated hemoglobin (HbA1c) on cardiovascular ...
Panpan He +10 more
doaj +1 more source
Salt-induced phosphoproteomic changes in the subfornical organ in rats with chronic kidney disease
Renal Failure, 2023 Objectives Subfornical organ (SFO) is vital in chronic kidney disease (CKD) progression caused by high salt levels. The current study investigated the effects of high salt on phosphoproteomic changes in SFO in CKD rats.Methods 5/6 nephrectomized rats ...
Xin Wang +5 more
doaj +1 more source
A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling
Nature Communications, 2022 Klotho is an anti-ageing protein whose expression is downregulated in chronic kidney disease, but the large size of the protein makes it challenging to deliver therapeutically.
Qian Yuan +11 more
doaj +1 more source