Results 61 to 70 of about 4,209,711 (302)

The cost of implementing UK guidelines for the management of chronic kidney disease [PDF]

, 2007
Background. Chronic kidney disease (CKD) is a major public health problem. In the UK, guidelines have been developed to facilitate case identification and management.
B. Klebe, Stevens, PE, H. Hobbs, Lamb, EJ, Cooley, R, Irving, J, Hobbs, H, D. J. O'Donoghue, Farmer, CKT, J. New, Middleton, R, S. de Lusignan, Klebe, B, J. Irving, O'Donoghue, DJ, John, I, R. Middleton, I. John, P. E. Stevens, R. Cooley, de Lusignan, S, New, J, C. K.T. Farmer, E. J. Lamb, Hobbs, Helen, John, Ian, Klebe, Bernhard, Middleton, Rachel, Stevens, Paul E., New, John, Cooley, Roger, Lamb, Edmund J., O'Donoghue, Donal J., Farmer, Chris, Irving, Jean, de Lusignan, Simon   +35 more
core   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Using Serum Interleukin-18 (IL-18) as a Biomarker of Chronic Kidney Failure and its relationship with Prolactin Level

Tikrit Journal of Pure Science, 2020
Kidney failure usually occurs as a result of lacking the normal functions of kidney as either partly or completely. In the last years, it was announced that the Interleukin-18 has received significant interest as inflame marker.
Wasan Abdul Malik Izz al-Din, , Nadia Ibrahim Salih   +1 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Correlation between Serum level of Troponin I and High Sensetive CRP in Renal transplant Patients

مجله دانشگاه علوم پزشکی بیرجند, 2013
Background and Aim: Accompaniment of high serum levels of CRP to troponin increases the mortality rate in dialysis patients, and both of them are considered to be independent risk factors for uremic cardiomyopathy.
Abbas Ali Zeraati, Farzaneh Sharifipour, Faezeh Rajabigol, Hourak Pourzand, Seyyed Seifollah Beladi Mousavi   +4 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Biochemical parameters of rat blood in the models of chronic heart failure and chronic kidney disease at the administration of nitric oxide donor

BIO Web of Conferences, 2020
In modern veterinary medicine, the simultaneous occurrence of chronic heart failure and chronic kidney disease is often found. However, the cause and effect often exchange places, which creates great difficulties in the animals’ treatment. Chlofusan acts
Akhmadeeva Ksenia, Belova Alisa, Karimova Rufiia   +2 more
doaj   +1 more source