Results 71 to 80 of about 4,209,711 (302)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Studi Penggunaan Obat Antihipertensi Pada Pasien Chronic Renal Failure

Indonesian Journal of Pharmaceutical Education
Kidney failure is a world health problem with increasing prevalence, morbidity, and mortality rates. Kidney disease is divided into 2, acute kidney failure (acute kidney disease) and chronic kidney failure (chronic kidney disease). Hypertension occurs in
Ni Made Maharianingsih, Dhiancinantyan Windidaca Brata Putri   +1 more
doaj   +1 more source

Effect of information and telephone-guided access to community support for people with chronic kidney disease: randomised controlled trial [PDF]

, 2014
BackgroundImplementation of self-management support in traditional primary care settings has proved difficult, encouraging the development of alternative models which actively link to community resources.
Peter Bower (52501), Christian Blickem, Christian Blickem (397641), Brooks Helen, Anne Rogers, Chew-Graham, C, Blakeman, T, Gerry Richardson (571072), Bower, P, David Reeves, Reeves, Davd, Blakeman, Tom, Dawson, S, Gaffney, H, Lee, V, David Reeves (164641), Mossabir Rahena, Tom Blakeman, Hannah Gaffney, Gardner Caroline, Reeves, D, Blickem, C, Victoria Lee, Bower, Peter; id_orcid, Hannah Gaffney (645995), Ivaylo Vassilev (397639), Blickem, Christian, Spackman, E, Anne Kennedy (397644), Victoria Lee (645997), Richardson, Gerry, Shoba Dawson (645999), Dawson Shoba, Helen Brooks (397642), Anne Rogers (397640), Mossabir, Rahena, Spackman, Eldon, Jariwala, P, Spackman Eldon, Shoba Dawson, Blakeman Tom, Gaffney Hannah, Gaffney, Hannah, Anne Kennedy, Praksha Jariwala, Mossabir, R, Vassilev Ivaylo, Chew-Graham Carolyn, Kennedy, A, Dawson, Shoba, Rahena Mossabir (646000), Vassilev, Ivaylo, Reeves, David, Helen Brooks, Praksha Jariwala (645998), Bower Peter, Richardson, G, Caroline Gardner, Jariwala Praksha, Brooks, Helen, Rogers, A, Reeves David, Caroline Gardner (645996), Brooks, H, Kennedy, Anne P., Peter Bower, Bower, Peter, Lee, Victoria, Carolyn Chew-Graham, Blakeman, Tom; id_orcid, Tom Blakeman (645994), Blickem Christian, Lee Victoria, Eldon Spackman, Rogers, Anne, Kennedy, Anne, Gardner, Caroline, Rogers Anne, Ivaylo Vassilev, Eldon Spackman (462402), Richardson Gerry, Gardner, C, Vassilev, I, Kennedy Anne, Rahena Mossabir, Jariwala, Praksha, Chew-Graham, Carolyn, Gerry Richardson, Carolyn Chew-Graham (615627)   +88 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

THE RELATIONSHIP BETWEEN FAMILY SOCIAL SUPPORT AND COMPLIANCE OF CHRONIC RENAL FAILURE PATIENTS UNDERGOING HEMODIALYSIS

Journal of Vocational Nursing
Introduction: Chronic kidney disease is defined as kidney damage that lasts long (chronic) and is characterized by a decrease in the kidney's ability to filter blood (GFR).
Adhe Dewanto, Lina Indrawati, Lisna Nuryanti   +2 more
doaj   +1 more source

Skin changes in chronic kidney disease

, 2017
Chronic kidney disease causes skin changes which may sometimes be the first sign of kidney failure. Specific skin changes include acquired perforating dermatosis, porphyria cutanea tarda, pseudoporphyria, calcinosis and nephrogenic systemic fibrosis. The
Joanna M. Przepiórka-Kosińska, Joanna Bartosińska, Grażyna Chodorowska, Dorota Krasowska, Katarzyna M. Chyl-Surdacka   +4 more
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

MECHANISMS OF THE KIDNEY DAMAGE IN CASE OF OBESITY AND METABOLIC SYNDROME (REVIEW)

Мать и дитя в Кузбассе, 2018
Obesity and metabolic syndrome influence the functions of body’s systems, provoke a progressive kidney damage and are development factors of chronic nephron number in reference to body mass. A long-term impact of these factors leads to glomerulosclerosis
Юлия Николаевна Шишкова, Наталья Николаевна Миняйлова, Юрий Иванович Ровда, Любовь Михайловна Казакова   +3 more
doaj  

Mineralocorticoid receptor antagonists: new extended roles in cardio- and nephroprotection

Медицинский совет, 2018
The article presents the contemporary views of the role of aldosterone in the progression of cardiovascular and renal diseases. It addresses matters related to the efficacy and safety of mineralocorticoid receptor antagonists in patients with chronic ...
A. M. Esayan, A. N. Nimgirova
doaj   +1 more source