Results 21 to 30 of about 1,048,911 (270)

Identification and localization of novel genes preferentially expressed in human kidney glomerulus [PDF]

Nephrology, 2008
Lino Muñoz Cuéllar, Hidehiko Fujinaka, Keiko Yamamoto, Masahito Miyamoto, Masayuki Tasaki, Linning Zhao, Tamer Ahmed Ismail, Eishin Yaoita, Yutaka Yoshida, Tadashi Yamamoto   +9 more
openalex   +2 more sources

Proteome studies, with emphasis on the kidney glomerulus

, 2012
Proteomics aims to link genes to protein expression and function. Proteomics is a very versatile and technology-dependent discipline and the development of mass spectrometry-based proteomics has advanced the understanding of the complex and dynamic nature of proteomes.
Sam Tryggvason
openalex   +3 more sources

Ultrasmall polymeric nanocarriers for drug delivery to podocytes in kidney glomerulus

Journal of Controlled Release, 2017
Riccardo Bruni, Paolo Possenti, Carlotta Bordignon, Min Li, Stefania Ordanini, Piergiorgio Messa, Maria Pia Rastaldi, Francesco Cellesi   +7 more
openalex   +3 more sources

Endothelin and the Glomerulus in Chronic Kidney Disease [PDF]

Seminars in Nephrology, 2015
Endothelin-1 (ET-1) is a 21-amino acid peptide with mitogenic and powerful vasoconstricting properties. Under healthy conditions, ET-1 is expressed constitutively in all cells of the glomerulus and participates in homeostasis of glomerular structure and filtration function.
Matthias, Barton, Andrey, Sorokin
openaire   +2 more sources

Analysis of the three dimensional structure of the kidney glomerulus capillary network

Scientific Reports, 2019
The capillary network of the kidney glomerulus filters small molecules from the blood. The glomerular 3D structure should help to understand its function, but it is poorly characterized.
M. Terasaki, J. C. Brunson, Justin Sardi
semanticscholar   +1 more source

Kidney Lipidomics by Mass Spectrometry Imaging: A Focus on the Glomerulus

International Journal of Molecular Sciences, 2019
Lipid disorders have been associated with glomerulopathies, a distinct type of renal pathologies, such as nephrotic syndrome. Global analyses targeting kidney lipids in this pathophysiologic context have been extensively performed, but most often ...
Imane Abbas, M. Noun, D. Touboul, Dil Sahali, A. Brunelle, M. Ollero   +5 more
semanticscholar   +1 more source

Signaling pathways of chronic kidney diseases, implications for therapeutics

Signal Transduction and Targeted Therapy, 2022
Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) deposition.
Q. Yuan, B. Tang, Chun Zhang
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Reduction in Renal Relapse and Preservation of Long‐Term Kidney Function After Lupus Low Disease Activity in Patients With Lupus Nephritis

Arthritis Care &Research, EarlyView.
Objective Lupus low disease activity state (LLDAS) is a validated treatment target in systemic lupus erythematosus (SLE), but limited studies have explored the role of LLDAS in lupus nephritis (LN). This study aims to investigate the frequency and predictors of LLDAS attainment and its benefit on LN relapse and renal function preservation in patients ...
Chak Kwan Cheung, Desmond Y. H. Yap, Ka Lai Lee, Philip H. Li, Iris Y. K. Tang, Chak Sing Lau, Shirley C. W. Chan   +6 more
wiley   +1 more source