Results 231 to 240 of about 86,303 (320)

Cathepsin B induces kidney diseases through different types of programmed cell death. [PDF]

Front Immunol
Zhao Y, Zhuang Y, Shi J, Fan H, Lv Q, Guo X.   +5 more
europepmc   +1 more source

Long‐term effects of metformin on offspring health: A review of current evidence and future directions

Diabetes, Obesity and Metabolism, Volume 27, Issue S3, Page 48-63, June 2025.
Abstract Metformin is widely prescribed for the management of type 2 diabetes mellitus, polycystic ovary syndrome, and gestational diabetes mellitus in pregnancy. Its use is driven by factors including oral administration, lower patient and health system burden and cost, and benefits including lower risk of excess gestational weight gain and ...
Tharaka Mayadunne, Saeede Saadati, Daniel Asmelash, Taitum Mason, Eszter Vanky, Helena Teede, Aya Mousa   +6 more
wiley   +1 more source

The ‘nephrotoxins’ were stopped: what is in a name and its impact on kidney and cardiac health?

Internal Medicine Journal, Volume 55, Issue 6, Page 1037-1041, June 2025.
Abstract The term ‘nephrotoxin’ is often imprecisely applied to medications that are not inherently toxic to the kidneys, including renin‐angiotensin‐aldosterone system inhibitors, sodium‐glucose co‐transporter 2 inhibitors, diuretics and metformin. These drugs are frequently included in ‘sick day rules’ and may be prematurely discontinued during acute
Catherine Mao, Bobby Chacko
wiley   +1 more source

Imaging Heterogeneous Patterns of Aminopeptidase N Activity in Hierarchical Tissue Structures Through High‐Resolution Whole‐Organ 3D Mapping

Angewandte Chemie, Volume 137, Issue 22, May 26, 2025.
Enzymes regulate physiological functions, and their abnormal activity is associated with diseases. Here, we present a method for high‐resolution 3D mapping of enzyme activity using tissue clearing and an activity‐based covalent probe. Focusing on aminopeptidase N, we developed ANA‐o‐BODIPY, which records enzyme activity via covalent labeling.
Bo Yi, Hiroyuki Yatabe, Daichi M. Sakamoto, Iori Tamura, Yutaro Saito, Naoki Yamada, Ruki Ashikaga, Masafumi Kuroda, Shimpei I. Kubota, Kazuki Tainaka, Shinsuke Sando   +10 more
wiley   +2 more sources

Does dihydromyricetin protect the kidney following ischemia–reperfusion injury in male rats?

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract Efforts to prevent the deleterious effects of the ischemia–reperfusion injury (IRI) on the kidney are ongoing. Recently, there has been an increasing interest in using natural phytochemical compounds as alternative remedies in several diseases.
Fayez T. Hammad, Loay Lubbad, Mariam Aljawder, Azza Al Ali, Suhail Al‐Salam, Awwab F. Hammad, Mustafa M. Ardah, M. Emdadul Haque, Jasmine Abdul Rasheed, Waheed F. Hammad   +9 more
wiley   +1 more source

Immunolocalization of Na(+)-Dependent Glucose Co-Transporters in Chicken Kidneys in Norm and During T-2 Mycotoxicosis (Primary Study). [PDF]

Curr Issues Mol Biol
Allmang C, Hussar P, Dūrītis I, Popovska-Percinic F.   +3 more
europepmc   +1 more source

SMYD2 Promotes Renal Tubular Cell Apoptosis and Chronic Kidney Disease Following Cisplatin Nephrotoxicity

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
SMYD2 mediates the activation of the NF‐κB signaling pathway to promote cisplatin‐induced chronic kidney injury. Cisplatin stimulation induces the upregulation of SMYD2 expression in renal tubular epithelial cells. SMYD2 promotes the phosphorylation of the p65 subunit of NF‐κB through methylation, thereby facilitating the release of inflammatory ...
Siyang Zuo, Huixiong Yuan, Xia Li, Ming Chen, Rui Peng, Siyu Chen, Xue Zou, Yuan Yang, Hehua Long, Zeying Liu, Teng Wang, Bing Guo, Lirong Liu   +12 more
wiley   +1 more source

Crescentic Glomerulonephritis Possibly Caused by COVID-19 Infection. [PDF]

J Clin Med
Errabelli P, Lathiya M, Mareedu N, Herrera Hernandez LP.   +3 more
europepmc   +1 more source

Meprin β Modulates Brevican Proteolysis Impairing Neural Plasticity and Memory Formation

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
Meprin β was studied using mice overexpressing it in cortical and hippocampal neurons. N‐terminomics identified brevican, a key extracellular matrix protein associated with synaptic plasticity and memory, as a potential substrate of meprin β. Further analyses revealed that brevican levels are dependent on the catalytic activity of meprin β.
Maximilian Keller, Celine Gallagher, Simon Kreiselmaier, Kira Bickenbach, Ulrich Schmitt, Liana Marengo, Dayan Taghikhah, Mohammad Abukhalaf, Andreas Tholey, Christoph Becker‐Pauly, Thomas Mittmann, Claus U. Pietrzik   +11 more
wiley   +1 more source

SOX9-dependent fibrosis drives renal function in nephronophthisis. [PDF]

EMBO Mol Med
Patel MM, Gerakopoulos V, Lettenmaier B, Petsouki E, Zimmerman KA, Sayer JA, Tsiokas L.   +6 more
europepmc   +1 more source