Results 51 to 60 of about 68,520 (162)

Targeting of reactive isolevuglandins in mitochondrial dysfunction and inflammation. [PDF]

, 2019
Inflammation is a major cause of morbidity and mortality in Western societies. Despite use of multiple drugs, both chronic and acute inflammation still represent major health burdens.
Amarnath, Venkataraman, Bridges, Christy C, Davies, Sean, Dikalov, Sergey, Dikalova, Anna, Mayorov, Vladimir, Moore, Christy S, Panov, Alexander V, Uchakin, Peter, Uzhachenko, Roman, Zackert, Bill   +10 more
core  

Evidence for a Disequilibrium pH in the Proximal Tubule of Rat Kidney.

Experimental Biology and Medicine, 1963
Reabsorption of filtered HCO3- by the kidney is thought to be mediated by secretion of cellular H+(1,2), resulting in the following intratubular reaction:Since dehydration of H2CO3 is not instantaneous, excess H2CO3 would accumulate in tubular fluid and would not be in equilibrium with plasma CO2.
Norman W. Carter, Floyd C. Rector
openaire   +3 more sources

Diabetic nephropathy, autophagy and proximal tubule protein endocytic transport: A potentially harmful relationship [PDF]

, 2018
Diabetic nephropathy (DN) is the most frequent cause of chronic renal failure. Until now, the pathophysiological mechanisms that determine its development and progression have not yet been elucidated.
Agüero, Rocio, Ezquer, Eduardo Marcelo, Ezquer, Fernando, Fader Kaiser, Claudio Marcelo, Giraud Billoud, Maximiliano German   +4 more
core  

Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ.

, 2015
Cystic kidney diseases (CKDs) affect millions of people worldwide. The defining pathological features are fluid-filled cysts developing from nephric tubules due to defective flow sensing, cell proliferation and differentiation.
Alexander, R., Alvarado, A., Lakshmanaperumal, N., McClain, M., McKinney, S., Rink, J., Vu, H.   +6 more
core   +1 more source

A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]

, 2019
Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song, Gao, Derek, Gaut, Joseph, Hoshi, Masato, Jain, Sanjay, Kim, Eric H., Knoten, Amanda, Lake, Blue B., Plongthongkum, Nongluk, Salamon, Diane, Venkatesh, Ramakrishna, Vijayan, Anitha, Zhang, Kun   +12 more
core   +2 more sources

Modeling the Effects of Multiple Myeloma on Kidney Function

, 2018
Multiple myeloma (MM), a plasma cell cancer, is associated with many health challenges, including damage to the kidney by tubulointerstitial fibrosis.
Ayati, Bruce P., Holstein, Sarah A., Walk, Julia C.   +2 more
core  

Can formaldehyde exposure induce histopathologic and morphometric changes on rat kidney? [¿la exposición al formaldehído puede inducir cambios histopatológicos y morfométricos sobre el riñón de rata?] [PDF]

, 2009
Formaldehyde is used traditionally for fixing the cadaver, and vaporized during dissection and practical studying on cadaver. This study was designed to determine the histopathologic and morphometric changes of rat kidney while all of the experiments ...
Azarhoush, R., Davarian, A., Fazeli, S.A., Ghafari, S., Golalipour, M.J.   +4 more
core  

Ultrastructure of the reproductive system of the black swamp snake (\u3ci\u3eSeminatrix pygaea\u3c/i\u3e). Part III. The sexual segment of the male kidney. [PDF]

, 2002
In mature male snakes and lizards, a distal portion of the nephron is hypertrophied in relation to its appearance in females and immature males. This sexual segment of the male kidney apparently provides seminal fluid that is mixed with sperm and ...
Sever, David M.
core   +1 more source

Effects of proximal tubule-specific ATRAP enhancement on hypertension in a remnant kidney chronic kidney disease model of mice. [PDF]

Sci Rep
Okami N, Wakui H, Tanaka S, Kobayashi R, Tsukamoto S, Taguchi S, Morita R, Kubo E, Yamashita A, Azushima K, Tamura K.   +10 more
europepmc   +1 more source

A case of chronic myelomonocytic related lysozyme-induced nephropathy. [PDF]

BMC Nephrol
Kansal A, Peiris T, Ramnarain J, Wang J, Daneshvar S, Chow F, Fleming S.   +6 more
europepmc   +1 more source