Na+–H+ exchanger-1 (NHE1) regulation in kidney proximal tubule [PDF]
The ubiquitously expressed plasma membrane Na(+)-H(+) exchanger NHE1 is a 12 transmembrane-spanning protein that directs important cell functions such as homeostatic intracellular volume and pH control. The 315 amino acid cytosolic tail of NHE1 binds plasma membrane phospholipids and multiple proteins that regulate additional, ion-translocation ...
Mark D, Parker +2 more
openaire +2 more sources
Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]
TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn +10 more
core +1 more source
Bioprinting Organs—Science or Fiction?—A Review From Students to Students
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu +18 more
wiley +1 more source
Objective To observe the distribution of membrane transporters, Megalin and Cubilin, in the renal development of mice, and to reveal the temporal and spatial rules of their functional differentiation during renal development.
LUO Mei, ZHAI Xiaoyue, MA Yunsheng
doaj +1 more source
Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. [PDF]
Obesity is a common and complex health problem, which impacts crucial organs; it is also considered an independent risk factor for chronic kidney disease.
Alessandra Stacchiotti +6 more
doaj +1 more source
Aquaporin-1 Facilitates Epithelial Cell Migration in Kidney Proximal Tubule [PDF]
Aquaporin-1 (AQP1) is the principal water-transporting protein in cell plasma membranes in kidney proximal tubule, where it facilitates transepithelial water transport. Here, a novel role for AQP1 in kidney involving the migration of proximal tubule cells is reported.
Mariko, Hara-Chikuma, A S, Verkman
openaire +2 more sources
AQP1 expression in the proximal tubule of diabetic rat kidney [PDF]
Polyuria is a hallmark symptom and the first clinical manifestation of diabetes mellitus (DM). The glucose that remains in renal tubules was proposed to produce an osmotic effect resulting in polyuria. Although water is reabsorbed in proximal tubules through an aquaporin-1 (AQP1) dependent mechanism, AQP1 role in the genesis of polyuria is unknown ...
Erika A. Seyahian +3 more
openaire +4 more sources
Canine liver transplantation under nva cyclosporine versus cyclosporine [PDF]
The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva 2-cyclosporine (Nva 2-CsA) were examined using canine orthotopic liver allografts.
DeWolf, A +6 more
core +1 more source
Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl +8 more
wiley +1 more source
Morfometría de cortes histológicos de los túbulos renales normales en una muestra de humanos adultos
Fundamento: los túbulos renales normales se han descrito por morfometría, lo que permite “reconstruir” en tercera dimensión la forma y el tamaño del espécimen estudiado.Objetivo: caracterizar la magnitud de los túbulos renales normales en humanos adultos,
Miosotis de Lourdes Fernández Lastre +4 more
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