Results 61 to 70 of about 73,145 (294)

Continuous growth of proximal tubular kidney epithelial cells in hormone-supplemented serum-free medium. [PDF]

, 1982
An epithelial cell line from pig kidney (LLC-PK1) with properties of proximal tubular cells can be maintained indefinitely in hormone-supplemented serum-free medium. Continuous growth requires the presence of seven factors: transferrin, insulin, selenium,
Chuman, L, Cohen, AH, Fine, LG, Saier, MH   +3 more
core  

PPARα contributes to protection against metabolic and inflammatory derangements associated with acute kidney injury in experimental sepsis [PDF]

, 2019
Sepsis‐associated acute kidney injury (AKI) is a significant problem in critically ill children and adults resulting in increased morbidity and mortality. Fundamental mechanisms contributing to sepsis‐associated AKI are poorly understood.
Bennion, Brock G, Djukovic, Danijel, Fei, Lin, Iwaki, Takuma, Liles, W. Conrad, Lynn, Jared C, Otinga, Cynthia, Raftery, Daniel, Standage, Stephen W, Stenson, Erin K, Wong, Hector R   +10 more
core   +2 more sources

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice

Journal of Diabetes Research, 2018
The kidney is an insulin-sensitive organ involved in glucose homeostasis. One major effect of insulin is to induce glycogen storage in the liver and muscle.
Romina Bertinat, Francisco Westermeier, Pamela Silva, Rodrigo Gatica, Joana Moitinho Oliveira, Francisco Nualart, Ramón Gomis, Alejandro J. Yáñez   +7 more
doaj   +1 more source

Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function

Nature Communications, 2022
Renal proximal tubules modulate whole-body homeostasis by sensing various nutrients. Here the authors describe the existence and importance of a unique CB1/mTORC1/GLUT2 signaling axis in regulating nutrient homeostasis in healthy and diseased kidney.
Liad Hinden, Majdoleen Ahmad, Sharleen Hamad, Alina Nemirovski, Gergő Szanda, Sandra Glasmacher, Aviram Kogot-Levin, Rinat Abramovitch, Bernard Thorens, Jürg Gertsch, Gil Leibowitz, Joseph Tam   +11 more
doaj   +1 more source

THE EFFECT OF CORIANDER LEAF EXTRACT TOWARDS KIDNEY HISTOPATHOLOGICAL FEATURES ON WISTAR RAT INDUCED BY ORALLY ADMINISTERED MERCURY

Jurnal Kedokteran Diponegoro, 2021
Background: Mercury’s a toxic heavy metal that damages the kidney through generation of Reactive Oxygen Species (ROS). Previous study has established that coriander leaves contained high level of antioxidants.
Manda Petrina, Ika Pawitra Miranti, Nani Maharani, Intan Rahmania Eka Dini   +3 more
doaj   +1 more source

Tubulointerstitial injury and proximal tubule albumin transport in early diabetic nephropathy induced by type 1 diabetes mellitus [PDF]

, 2017
A decrease in the tubular expression of albumin endocytic transporters megalin and cubilin has been associated with diabetic nephropathy (DN), but there are no comprehensive studies to date relating early tubulointerstitial injury and the effect of the ...
Bahamonde, Javiera, Ezquer, Fernando, Ezquer, Marcelo, Giraud Billoud, Maximiliano German   +3 more
core  

Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros [PDF]

, 2009
Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive.
Jones, E. A., Naylor, Richard William
core   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Research progress on the mechanism of kidney proximal tubule NHE3 in the angiotensin Ⅱ-dependent hypertension

Guangxi Yike Daxue xuebao
Hypertension is a multifactorial disorder involving genetic susceptibility, neuroendocrine dysregulation, cardiovascular and kidney dysfunction, and dietary factors.
LI Xiaochun, ZHUO Jialong, ZHENG Xiaowen, ZHAO Chunling, ZHANG Jianfeng, JIANG Yueming   +5 more
doaj   +1 more source