Results 91 to 100 of about 139,844 (303)

The Kidney and Uremic Toxin Removal: Glomerulus or Tubule? [PDF]

Seminars in Nephrology, 2014
Chronic kidney disease (CKD) is a condition that affects approximately 10% of the adult population in developed countries. In patients with CKD adequate renal clearance is compromised, resulting in the accumulation of a plethora of uremic solutes.
Masereeuw, R., Masereeuw, R., Mutsaers, H.A.M., Mutsaers, H.A.M., Mutsaers, H.A.M., Toyohara, T., Abe, T., Jhawar, S., Sweet, D.H., Lowenstein, J.   +9 more
openaire   +4 more sources

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source

Renal involvement in systemic lupus erythematosus: additional histopathological lesions

Archives of Medical Science, 2020
A common criticism of the classification of lupus nephritis is the relative scarcity of information regarding tubular, interstitial, and vascular changes compared to the available information regarding glomerular changes, even though their potential for ...
Monique Pereira Rêgo Muniz, Laise Pereira Arcoverde Fechine Brito, Pedro Henrique Cavalcante Vale, Felipe Leite Guedes, Thina Klicia Mendonça Oliveira, Dyego José de Araújo Brito, Natalino Salgado Filho, Márcio Dantas, Gyl Eanes Barros Silva   +8 more
doaj   +1 more source

Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas [PDF]

, 2016
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze, Briones, Ana M., Burns, Kevin, Callera, Glaucia, Correa, Jose, Gutsol, Alexey, He, Ying, Montezano, Augusto C., Moorman, Danielle, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.   +10 more
core   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Distribution of Galactose-N Acetyl Galactoseamine on the surface of adult mice kidney cells

مجله دانشگاه علوم پزشکی گرگان, 2004
Background&Objective: Carbohydrate chains link to glycoproteins and glycolipids of the cell surface particulary their terminal sugars have key roles in cellular activities of almost all biological systems.
H.Mofidpour (Ph.D), R.Ghorbanei (Ph.D), M.Jafarpour (Ph.D), AR.Fazel (Ph.D)   +3 more
doaj  

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

Effects of oxymetholone on kidney tissue of one-day old offspring of pregnant rats [PDF]

فصلنامه دانشگاه علوم پزشکی جهرم, 2011
Introduction:Oxymetholone is a drug used by some athletes as energy booster. However, its overuse may result in disorders such as lung cancer, ovarian cycle irregularities, liver cancer and adenoma of renal tubules.
Hojjatollah Karimi Jashni, Shamsi Bandak, Amir Ashkan Mahjoor   +2 more
doaj  

Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). [PDF]

, 1979
Madin-Darby canine kidney (MDCK) cells grown in tissue culture have the morphological properties of distal tubular epithelial cells, form tight junctions, and lack several proximal tubular enzyme markers.
Chuman, LM, Rindler, MJ, Saier, MH, Shaffer, L   +3 more
core