Cadmium Uptake by Kidney Distal Convoluted Tubule Cells
Toxicology and Applied Pharmacology, 1994 Cadmium is transported by and accumulated in the kidney, which is a primary site of its toxicity. Most cadmium is reabsorbed and accumulated by proximal tubules. However, evidence for distal tubule toxicity suggests that transport may also proceed at that nephron site.
P A, Friedman, F A, Gesek
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Atomically precise metal cluster enzymes for pathological tissue regeneration
BMEMat, EarlyView.Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong +11 more
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ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules. [PDF]
J Clin Invest, 2023 Mukhi D +18 more
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Retention of differentiated properties in an established dog kidney epithelial cell line (MDCK). [PDF]
, 1979 Madin-Darby canine kidney (MDCK) cells grown in tissue culture have the morphological properties of distal tubular epithelial cells, form tight junctions, and lack several proximal tubular enzyme markers.
Chuman, LM +3 more
core
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
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Clinical Pharmacology &Therapeutics, EarlyView.Cadmium exposure causes serious health consequences; however, there is no clinically approved antidote for cadmium poisoning. This Phase 1a/1b trial aimed to investigate safety, tolerability, and pharmacokinetics of Sodium (S)‐2‐(dithiocarboxylato((2S,3R,4R,5R)‐2,3,4,5,6‐pentahydroxyhexyl) amino)‐4‐(methylthio) butanoate (GMDTC), a novel chelating ...
Xuefeng Ren +21 more
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The kidney transcriptome and proteome defined by transcriptomics and antibody-based profiling.
PLoS ONE, 2014 To understand renal functions and disease, it is important to define the molecular constituents of the various compartments of the kidney. Here, we used comparative transcriptomic analysis of all major organs and tissues in the human body, in combination
Masato Habuka +9 more
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Associations of CKD risk factors and longitudinal changes in urine biomarkers of kidney tubules among women living with HIV. [PDF]
BMC Nephrol, 2021 Muiru AN +15 more
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Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse. [PDF]
, 2019 Homomeric α7 nicotinic acetylcholine receptors (nAChRs) are abundantly expressed in the central and peripheral nervous system (CNS and PNS, respectively), and spinal cord.
Broide, Ron S +3 more
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Clinical Pharmacology &Therapeutics, EarlyView.Target trial emulation of a multi‐institutional electronic health record network showed comparable cardiorenal effectiveness and safety of dapagliflozin versus empagliflozin in adults with type 2 diabetes and advanced‐stage chronic kidney disease.
Shih‐Hsuan Lin +6 more
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