Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype [PDF]
Cells, 2022 Nephropathic cystinosis is a rare and severe disease caused by disruptions in the CTNS gene. Cystinosis is characterized by lysosomal cystine accumulation, vesicle trafficking impairment, oxidative stress, and apoptosis. Additionally, cystinotic patients
Elena Sendino Garví +2 more
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Engineered Kidney Tubules for Modeling Patient-Specific Diseases and Drug Discovery [PDF]
EBioMedicine, 2018 The lack of engineering systems able to faithfully reproduce complex kidney structures in vitro has made it difficult to efficiently model kidney diseases and development.
Valentina Benedetti +9 more
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Exploring mitophagy levels in Drosophila Malpighian tubules unveils the pivotal role of mitophagy in kidney function and diabetic kidney disease [PDF]
Experimental and Molecular MedicineMitophagy has been implicated in kidney function and related diseases. However, a direct analysis of mitophagy in kidney models, including disease models, remains notably lacking.
Kang-Min Lee +8 more
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Kidney tubules: intertubular, vascular, and glomerular cross-talk. [PDF]
Curr Opin Nephrol Hypertens, 2016 The kidney mediates the excretion or conservation of water and electrolytes in the face of changing fluid and salt intake and losses. To ultrafilter and reabsorb the exact quantities of free water and salts to maintain euvolemia a range of endocrine, paracrine, and hormonal signaling systems have evolved linking the tubules, capillaries, glomeruli ...
Ferenbach DA, Bonventre JV.
europepmc +5 more sources
Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation [PDF]
Scientific ReportsAcute kidney injury (AKI) can progress to chronic kidney disease (CKD), via a mechanism that is still largely unknown. We previously reported that glucosylceramide (GlcCer) acts as a damage-associated molecular pattern (DAMP) during AKI.
Akinori Osada +14 more
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Bioengineered kidney tubules efficiently excrete uremic toxins. [PDF]
Sci Rep, 2016 AbstractThe development of a biotechnological platform for the removal of waste products (e.g. uremic toxins), often bound to proteins in plasma, is a prerequisite to improve current treatment modalities for patients suffering from end stage renal disease (ESRD).
Jansen J +12 more
europepmc +6 more sources
Fine Structure of the Trunk Kidney and Distribution of Its Secreted Exosomes in the Adult Zebrafish
Shiyan dongwu yu bijiao yixue, 2023 Objective To observe the fine structure of the trunk kidney in zebrafish, and to identify its secreted exosomes.Methods The microstructure and ultrastructure of the trunk kidney in zebrafish were observed by light microscopy and electron microscopy, and ...
LIN Jinxing +5 more
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Histological Characteristics of the Kidney in Mongolian Gerbils of Different Ages
Shiyan dongwu yu bijiao yixue, 2023 ObjectiveTo explore the histological characteristics of the kidney in Mongolian gerbils of different ages.MethodsTen Mongolian gerbils of 2, 6, and 12 months old (half male and half female) were selected.
LU Lingqun +4 more
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Expression of Bcl-2 and Bax in mouse renal tubules during kidney development. [PDF]
PLoS ONE, 2012 Bcl-2 and Bax play an important role in apoptosis regulation, as well as in cell adhesion and migration during kidney morphogenesis, which is structurally and functionally related to mitochondria.
Xiao-Feng Song +4 more
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Morphological description and histological structure of the Hedgehog Kidney (Hemiechinus auritus)
Tikrit Journal of Pure Science, 2023 This study was aimed to recognize the morphological description and histological structure of the kidney in hedgehog (Hemiechinus auritus). The morphological results showed that the kidney has a small bean shape and reddish brown color.
Thekra Atta +4 more
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