Minimal Kidney Disease Phenotype in Heterozygous Null Mice
Canadian Journal of Kidney Health and Disease, 2023 Background: Shroom family member 3 (SHROOM3) encodes an actin-associated protein that regulates epithelial morphology during development. Several genome-wide association studies (GWAS) have identified genetic variances primarily in the 5’ region of ...
Allison Lawlor +9 more
doaj +1 more source
Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production [PDF]
, 1995 EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright. Research articles from EHP may be used freely; however, articles from the News section of EHP may contain photographs or ...
Albro P +8 more
core +2 more sources
Differential Expression Of Gap Junction mRNAs And Proteins In The Developing Murine Kidney And In Experimentally Induced Nephric Mesenchymes [PDF]
, 1992 The expression of three gap junction (GJ) proteins, alpha-1 (Cx43), beta-1 (Cx32), and beta-2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney. These proteins were expressed in two non-overlapping patterns.
Gilbert, Scott F. +6 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Pulsatile flow through idealized renal tubules: Fluid-structure interaction and dynamic pathologies
Mathematical Biosciences and Engineering, 2020 Kidney tubules are lined with flow-sensing structures, yet information about the flow itself is not easily obtained. We aim to generate a multiscale biomechanical model for analyzing fluid flow and fluid-structure interactions within an elastic kidney ...
Niksa Praljak +2 more
doaj +1 more source
Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila. [PDF]
PLoS Genetics, 2017 Progressive cystic kidney degeneration underlies diverse renal diseases, including the most common cause of kidney failure, autosomal dominant Polycystic Kidney Disease (PKD).
Chiara Gamberi +3 more
doaj +1 more source
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Journal of Tropical Life Science, 2019 Diabetic nephropathy is one of the diabetes complications attacking kidney leading to kidney damage. Hyperglycemia accompanying DM causes the increase of Ad-vanced Glycation End-Product (AGE) and Receptor Advanced Glycation End-Product (RAGE) activity ...
Abdul Gofur +5 more
doaj +1 more source
Cell & Bioscience, 2022 Background The kidneys require vast amounts of mitochondria to provide ample energy to reabsorb nutrients and regulate electrolyte, fluid, and blood pressure homeostasis.
Yapei Yuan +9 more
doaj +1 more source
Struktur Ginjal Ikan Selais (Ompokhypopthalmusbleeker, 1846) Di Perairan Sungai Siak Kota Pekanbaru [PDF]
, 2014 This study aims to find out histological condition of kidney tissue of selais fish (Ompok hypophthalmus) from Siak river. Kidney samples of the fish were collected from two stations, namely Siak I Bridge in Okura Village, District Rumbai Pesisir and Siak
Elvyra, R. (Roza) +2 more
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