Results 91 to 100 of about 639,100 (318)

Natural killer cell-derived exosome-based cancer therapy: from biological roles to clinical significance and implications

Molecular Cancer
Natural killer (NK) cells are important immune cells in the organism and are the third major type of lymphocytes besides T cells and B cells, which play an important function in cancer therapy.
Chaohua Si, Jianen Gao, Xu Ma
doaj   +1 more source

Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing αβ+T and B cell-depleted hematopoietic stem cell transplantation for hematological malignancies

Haematologica, 2016
We analyzed the impact of human cytomegalovirus infection on the development of natural killer cells in 27 pediatric patients affected by hematological malignancies, who had received a HLA-haploidentical hematopoietic stem cell transplantation, depleted ...
Letizia Muccio, Alice Bertaina, Michela Falco, Daniela Pende, Raffaella Meazza, Miguel Lopez-Botet, Lorenzo Moretta, Franco Locatelli, Alessandro Moretta, Mariella Della Chiesa   +9 more
doaj   +1 more source

CINs of the cytoplasm: dissecting dsRNA signaling in chromosomal instability

Molecular Oncology, EarlyView.
Micronuclei, formed during cell division in chromosomal instability settings, rupture and lead to the accumulation of immunogenic double‐stranded RNA in the cytoplasm, activating MAVS‐dependent interferon signaling and innate antitumor immunity.
Aglaia Skolariki, Rose L. Jady‐Clark, Eileen E. Parkes   +2 more
wiley   +1 more source

Appearance-free Tripartite Matching for Multiple Object Tracking [PDF]

arXiv, 2020
Multiple Object Tracking (MOT) detects the trajectories of multiple objects given an input video. It has become more and more important for various research and industry areas, such as cell tracking for biomedical research and human tracking in video surveillance.
arxiv  

Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice [PDF]

, 2017
Congenital cytomegalovirus (CMV) infection is the most common non-hereditary cause of sensorineural hearing loss (SNHL) yet the mechanisms of hearing loss remain obscure.
A Honeycutt, AA Scalzo, AA Scalzo, AH Park, AH Park, AH Park, Albert H. Park, Ali A. Almishaal, Anne Zhang, B Polic, BA Parikh, CA Biron, CC Morton, Elaine Hillas, FR Pass, H Arase, HR Smith, HT Reyburn, I Bubic, I Kosugi, JF Bukowski, Jun Yang, K Ikuta, KB Fowler, KB Fowler, KB Fowler, KR Stratton, L Hao, L Song, Liting Chen, Matthew A. Firpo, ML Engman, N Terrazzini, PD Mathur, Pranav D. Mathur, R Gazit, RD Bradford, Robert F. Kalejta, S Jonjic, SD Grosse, SJ Schachtele, TP Cheng, TP Cheng, V Bekiaris, V Prod'homme, Wayne M. Yokoyama, X Li, Y Gan, Y Wang, Yong Wang   +49 more
core   +5 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Natural Killer Cell and Large Granular Lymphocyte Deficiency in the Gut of Children with Inflammatory Bowel Disease

Canadian Journal of Gastroenterology, 1990
The occurrence of natural killer cells and large granular lymphocytes (LGL) within the epithelium of colonic mucosa in children with inflammatory bowel disease (IBD) was compared to normal controls.
F Hadziselimovic, LR Emmons, U Schaub
doaj   +1 more source

Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells [PDF]

, 2019
Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state.
Andhey, Prabhakar, Artyomov, Maxim, Bern, Michael, Collins, Patrick, Colonna, Marco, Hershey, Maxwell, Murphy, Kenneth M, Oltz, Eugene, Park, Eugene, Patel, Swapneel, Plougastel-Douglas, Beatrice, Porter, Sophia, Sibley, L David, Wang, Qiuling, Yokoyama, Wayne M, Zaitsev, Konstantin   +15 more
core   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Células natural killer e vigilância imunológica Natural killer cells and immune surveillance

Jornal de Pediatria, 2008
OBJETIVOS: Analisar a importância das células natural killer, de seus receptores killer immunoglobulin-like receptors e correspondentes genes (KIR) na vigilância imunológica do organismo contra agentes infecciosos, transplantes de células-tronco ...
Mariana Jobim, Luiz F. J. Jobim
doaj   +1 more source