Results 201 to 210 of about 219,366 (265)

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

GNAQ inhibits tumorigenesis via the ARHGEF25-mediated RHOA pathway in NK/T-cell lymphoma. [PDF]

Cancer Biol Ther
Gao Y, Zhang Z, Song Y, Song W, Li H, Zhang L, Li Z, Zhang M.   +7 more
europepmc   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Immune response in dogs with myxomatous mitral valve disease: insights into monocyte and lymphocyte subtypes and natural killer cells. [PDF]

J Vet Intern Med
Cimerman M, Nemec Svete A, Baš A, Hajdinjak M, Bajc M, Petek S, Pohar K, Ihan A, Krapež U, Krt B, Dolinar K, Miš K, Pirkmajer S, Domanjko Petrič A.   +13 more
europepmc   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

Correction: Combined IFN-γ and TNF-α treatment enhances the susceptibility of breast cancer cells and spheroids to Natural Killer cell-mediated killing. [PDF]

Cell Death Dis
Barberini F, Pietroni R, Ielpo S, Lucarini V, Nardozi D, Melaiu O, Benvenuto M, Focaccetti C, Palumbo C, Rossin F, Fruci D, Olive D, Masuelli L, Bei R, Cifaldi L.   +14 more
europepmc   +1 more source

Flow cytometric analysis of the immune cell subsets in adult hemophagocytic lymphohistiocytosis. [PDF]

Front Immunol
Qin Y, Zhou J, Liu P, Dai Y, Tang Y, Zhong X, Chen X, Zhu H, Liu T.   +8 more
europepmc   +1 more source

Single-patient single-cell RNA sequencing reveals neuroendocrine predominance and immunosuppression in small-cell lung cancer. [PDF]

Transl Cancer Res
Wang Y, He S, Wang R, Huang W.
europepmc   +1 more source