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Current Opinion in Immunology, 1995
In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling ...
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In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling ...
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Natural Killer Cells for Osteosarcoma
2014Natural killer (NK) cells are lymphocytes of the innate immune system that have the ability to recognize malignant cells through detection of a variety of cell-surface indicators of stress and danger. Once activated through such recognition, NK cells release cytokines and induce target cell lysis through a variety of mechanisms.
Nidale, Tarek, Dean A, Lee
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Natural killer cells and autoimmunity
Immunologic Research, 1989In various autoimmune diseases it appears that NK activity is impaired, and that this phenomenon is significant in disease development. Impairment of NK activity may be the result of two different mechanisms. In systemic autoimmune diseases, in which various target organs are involved (nonorgan-specific), the peripheral blood NK level is generally ...
E, Grunebaum +2 more
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Natural killer cells and their receptors
Transplant Immunology, 2002Natural killer (NK) cells have been known for a long time to be a very important component of the innate immune system. However, it is only during the last 10 years that knowledge of their receptors has emerged. Described in the present review are those receptor families killer inhibitory receptor (KIR) (belonging to the immunoglobulin superfamily ...
Derek, Middleton +2 more
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Improving natural killer cells
Cytotherapy, 2008Donor lymphocyte infusions after stem cell transplantation have taught the cancer community that human immune cells have the potential power to control growth of and even eliminate a malignant clone. Although infusion of allogeneic T lymphocytes after stem cell transplantation has become part of the treatment algorithm, either to prevent or treat ...
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The enigma of the natural killer cell
Nature, 1995Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants.
J E, Gumperz, P, Parham
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Immunoregulation and natural killer cells
Molecular Immunology, 1982Natural killer (NK) cells have a cytotoxic activity against a variety of tumor cells and also against some microorganisms or cells infected by microbial agents. They may thereby serve as important effector cells in host resistance against disease. NK cells are present in virtually all individuals, can be activated rapidly by a wide range of stimuli ...
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Functions of natural killer cells
Nature Immunology, 2008Natural killer (NK) cells are effector lymphocytes of the innate immune system that control several types of tumors and microbial infections by limiting their spread and subsequent tissue damage. Recent research highlights the fact that NK cells are also regulatory cells engaged in reciprocal interactions with dendritic cells, macrophages, T cells and ...
Vivier, Eric +4 more
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Veterinary Immunology and Immunopathology, 2009
Natural killer (NK) cells have received much attention due to their cytotoxic abilities, often with a focus on their implications for cancer and transplantation. But despite their name, NK cells are also potent producers of cytokines like interferon-gamma.
Preben, Boysen, Anne K, Storset
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Natural killer (NK) cells have received much attention due to their cytotoxic abilities, often with a focus on their implications for cancer and transplantation. But despite their name, NK cells are also potent producers of cytokines like interferon-gamma.
Preben, Boysen, Anne K, Storset
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1996
Natural Killer (NK) cells represent a distinct lymphoid lineage. These cells were initially defined functionally by their ability to kill certain virally infected cells and tumor cells (reviewed in Trinchieri 1989; Ritz et al. 1988). This unique function and its evolutionary conservation led to the classification of NK cells as part of the innate ...
T W, Göbel, C H, Chen, M D, Cooper
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Natural Killer (NK) cells represent a distinct lymphoid lineage. These cells were initially defined functionally by their ability to kill certain virally infected cells and tumor cells (reviewed in Trinchieri 1989; Ritz et al. 1988). This unique function and its evolutionary conservation led to the classification of NK cells as part of the innate ...
T W, Göbel, C H, Chen, M D, Cooper
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