Results 141 to 150 of about 2,580,938 (299)

Insulin Activates Protein Kinases C-ζ and C-λ by an Autophosphorylation-dependent Mechanism and Stimulates Their Translocation to GLUT4 Vesicles and Other Membrane Fractions in Rat Adipocytes [PDF]

, 1999
Mary L. Standaert, Gautam Bandyopadhyay, Liliam Perez, Debbie Price, Lamar Galloway, Andrew Poklepovic, Minni P. Sajan, Vittoria Cenni, Alessandra Sirri, Jorge Moscat, Alex Toker, Robert V. Farese   +11 more
openalex   +1 more source

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Proceedings of the National Academy of Sciences of the United States of America, 1995
D. T. Dudley, L. Pang, S. Decker, A. Bridges, A. Saltiel   +4 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM. [PDF]

Nat Commun
Matsushima K, Sumikama T, Suzuki T, Ito M, Nagasawa Y, Sumino A, Flechsig H, Ogoshi T, Umeda K, Kodera N, Murakoshi H, Shibata M.   +11 more
europepmc   +1 more source

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1 [PDF]

, 2000
Nicholas R. Helps, Xinmei Luo, Hazel M. Barker, Patricia T.W. Cohen   +3 more
openalex   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

In Silico Identification of Lepiotaprocerin C as a Promising PIM-1 Kinase Inhibitor: An Integrated Docking, Molecular Dynamics, MM/PBSA, QSAR, and ADMET Study. [PDF]

Bioinform Biol Insights
Ks K, Ibraheem FQ, Thapa S, Metri SM, Shaik S, Kurmi SPC, Chowdhury A, Mishra VK, T P.   +8 more
europepmc   +1 more source

Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase

, 2020
Jinho Heo, James M. Larner, David L. Brautigan   +2 more
openalex   +1 more source

Transforming Growth Factor-β and Platelet-Derived Growth Factor Signal via c-Jun N-Terminal Kinase-Dependent Smad2/3 Phosphorylation in Rat Hepatic Stellate Cells after Acute Liver Injury [PDF]

, 2005
Katsunori Yoshida, Koichi Matsuzaki, Shigeo Mori, Yoshiya Tahashi, Hideo Yamagata, Fukiko Furukawa, Toshihito Seki, Mikio Nishizawa, Jun–ichi Fujisawa, Kazuichi Okazaki   +9 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source