Results 191 to 200 of about 2,580,938 (299)

Decoding TREM2 Signaling Pathways: Linking Macrophage Glycolysis to Inflammatory Diseases in the CNS. [PDF]

Neurol Neuroimmunol Neuroinflamm
Che Y, Yu Z, Ji S, Yang D.
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Efficacy of larotrectinib in pediatric cancers with <i>NTRK</i> gene fusions. [PDF]

Transl Pediatr
Houghton PJ, Bjornsti MA.
europepmc   +1 more source

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

Oncogene, 2007
P. Roberts, C. Der
semanticscholar   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Dual Phosphorylation of Thr175 and Ser176 Is Essential for SnRK1α1 Activation. [PDF]

Physiol Plant
Ávila A, López A, Cervantes J, Rodríguez-Sotres R, Martínez-Barajas E, Coello P.   +5 more
europepmc   +1 more source

Src Kinase Phosphorylates RUNX3 at Tyrosine Residues and Localizes the Protein in the Cytoplasm [PDF]

, 2010
Yun‐Mi Goh, Senthilkumar Cinghu, Eileen Tan Hwee Hong, You‐Soub Lee, Jang‐Hyun Kim, Juwon Jang, Yinghui Li, Xin‐Zi Chi, Kyeong‐Sook Lee, Hee‐Jun Wee, Yoshiaki Ito, Byung‐Chul Oh, Suk‐Chul Bae   +12 more
openalex   +1 more source

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Current Biology, 1997
D. Alessi, S. James, C. Downes, A. Holmes, P. Gaffney, C. Reese, P. Cohen   +6 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Structural insights and biophysical characterization of p90RSK2:ERK2 complex. [PDF]

Biochem J
Kobori EK, Nguyen HPM, Wu J, Chen K, Malinovski R, Taylor S.   +5 more
europepmc   +1 more source