Results 201 to 210 of about 2,580,938 (299)

Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase

, 2002
Claudio Sette
openalex   +2 more sources

Protein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress [PDF]

, 2017
Ranjan Kumar Mishra, Frank van Drogen, Reinhard Dechant, Soojung Oh, Noo Li Jeon, Sung Sik Lee, Matthias Peter   +6 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Overcoming the sorafenib resistance mechanism in FLT3-mutated acute myeloid leukemia: molecular basis and new targets. [PDF]

Front Oncol
Peng H, Li M, Peng YY, Li XL, Yang J, Sun QG, Song K.   +6 more
europepmc   +1 more source

CD14 Mediates Toll-like Receptor 4 (TLR4) Endocytosis and Spleen Tyrosine Kinase (Syk) and Interferon Regulatory Transcription Factor 3 (IRF3) Activation in Epithelial Cells and Impairs Neutrophil Infiltration and Pseudomonas aeruginosa Killing in Vivo [PDF]

, 2013
Sanhita Roy, Mausita Karmakar, Eric Pearlman   +2 more
openalex   +1 more source

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Science, 2011
Daniel F Egan, D. Shackelford, M. Mihaylova, Sara Gelino, Rebecca A. Kohnz, William B. Mair, Debbie S. Vasquez, Aashish Joshi, Dana M. Gwinn, Rebecca C. Taylor, J. Asara, J. Fitzpatrick, A. Dillin, B. Viollet, M. Kundu, M. Hansen, R. Shaw   +16 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

PAK1 (p21-Activated Kinase 1) and Its Role in Neurodevelopmental Disorders-New Case Report and a Comprehensive Review. [PDF]

Int J Mol Sci
Blek N, Pielas M, Kharytonov V, Rutkowska K, Rusecka J, Lewicki S, Płoski R, Zwoliński P.   +7 more
europepmc   +1 more source

The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in Drosophila

, 2005
David J. Forsthoefel, Eric C. Liebl, Peter A. Kolodziej, Mark A. Seeger   +3 more
openalex   +1 more source

Targeting the phosphoinositide 3-kinase pathway in cancer

Nature reviews. Drug discovery, 2009
Pixu Liu, Hailing Cheng, T. Roberts, Jean J. Zhao   +3 more
semanticscholar   +1 more source