Results 241 to 250 of about 3,771,587 (392)

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

Oncogene, 2007
P. Roberts, C. Der
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

DeepKinome: quantitative prediction of kinase binding affinity by a compound using deep learning based regression model. [PDF]

Front Mol Biosci
Lee Y, Eun J, Lee J, Nam S.
europepmc   +1 more source

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Current Biology, 1997
D. Alessi, S. James, C. Downes, A. Holmes, P. Gaffney, C. Reese, P. Cohen   +6 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Discovery of N8: a novel IKKε inhibitor with potent anticancer activity via cytotoxicity, migration suppression, and autophagy modulation. [PDF]

J Enzyme Inhib Med Chem
Ye W, Zheng S, Xie H, Zhou X, Xu J, Luo Q, Huang Y, Li J, Diao J, Luo X, Zhu Q, Liu G.   +11 more
europepmc   +1 more source

Protein Kinase Mzeta (PKM-ζ) Regulates Kv1.2 Dependent Cerebellar Eyeblink Classical Conditioning

, 2017
Kutibh Chihabi
openalex   +1 more source

Computational Design of Aminopyrimidine Derivatives with FDA-Approved Anticancer Drugs and their ADMET Pharmacokinetics and Molecular Docking Evaluation against Cancer-Inducing AXL Kinase Activity

openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket. [PDF]

Protein Sci
Verma J, Vashisth H.
europepmc   +1 more source