Results 301 to 310 of about 2,849,925 (342)

Post-translational modifications in anaplastic thyroid carcinoma: biological mechanisms and therapeutic potential. [PDF]

Cancer Cell Int
Zhong L, Li H, Miao J, Zhang K, Cui L, Wang Z.   +5 more
europepmc   +1 more source

Effectiveness and safety of baricitinib for juvenile idiopathic arthritis associated uveitis or chronic anterior antinuclear antibody positive uveitis

Arthritis Care &Research, Accepted Article.
Objectives Evaluate the efficacy and safety of baricitinib in paediatric patients with active JIA‐U or chronic anterior ANA‐positive uveitis, who had an inadequate response to MTX or bDMARDs. Methods JUVE‐BRIGHT was an open‐label, active‐controlled, Phase‐3 multicentre trial which utilized a novel design, including 1:1 randomization to an active ...
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Relationship between creatine kinase and gastric cancer: A two-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Tu Y, Xie D, Qian H.
europepmc   +1 more source

Clinical Outcomes Of Patients Within The Rheumatoid Arthritis Care Pathway Cohort At a Tertiary Care Integrated Delivery Network: A Comparison To Usual Care

Arthritis Care &Research, Accepted Article.
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multi‐disciplinary team‐based care. Clinical and insurance claims data were extracted to compare
Tarun Sharma, Tyson S. Barrett, Teigan Dwyer, Nancy Campbell, Jessica Heintzinger, Ellen Kraemer, Adam Dore, Susan Manzi   +7 more
wiley   +1 more source

Focal adhesion kinase: A promising regulator of colitis-associated healing. [PDF]

World J Gastroenterol
Malek KK, Kumar B, Ahmad R, Singh A, Basson MD.   +4 more
europepmc   +1 more source

Temporal trends in and associations with nonsteroidal anti‐inflammatory drug prescription in adult and pediatric patients with inflammatory bowel disease

Arthritis Care &Research, Accepted Article.
Objective Recent inflammatory bowel disease (IBD) treatment guidelines have recommended against NSAID use despite prevalent musculoskeletal symptoms and opioid overuse in this population. Given the discordance between changing national guidelines and potential clinical utility, we sought to assess national temporal trends in prescription NSAID and ...
Adam S. Mayer, Rui Xiao, Andrew Grossman, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +5 more
wiley   +1 more source

Leveraging artificial intelligence and machine learning in kinase inhibitor development: advances, challenges, and future prospects. [PDF]

RSC Med Chem
Elgawish MS, Almatary AM, Zaitone SA, Salem MSH.   +3 more
europepmc   +1 more source

Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases. [PDF]

J Biol Chem
Lu JD, Zhao P, Prasad A, Gupta N, Gravel N, Shidhaye T, Wells L, Katiyar S, Kannan N.   +8 more
europepmc   +1 more source

Comparative Molecular Dynamics Reveals How LRRK2 Inhibitors Distinguish G2019S from Wild-Type. [PDF]

Neurochem Res
Wei C, Heh CH, Lit LC, Chin SP.
europepmc   +1 more source

Targeted design, synthesis, molecular dynamics, ADME and in -vitro anticancer assessment of oxo-tetrahydro-pyrimidin-benzenesulfonamide hybrids as potential BRAF^V600E inhibitors. [PDF]

Sci Rep
Singh AK, Kumar A, Singh H, Pathak P, Verma A, Khalilullah H, Jaremko M, Emwas AH, Novak J, Kumar P.   +9 more
europepmc   +1 more source