Results 341 to 350 of about 3,607,204 (411)
Some of the next articles are maybe not open access.
The phosphoinositide 3-kinase pathway.
Science, 2002Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components.
L. Cantley
semanticscholar +1 more source
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Science, 1988In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not through the traditional biochemical approach of protein purification and enzyme assay, but as putative protein kinase amino ...
S. Hanks, A. Quinn, T. Hunter
semanticscholar +1 more source
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
Frontiers in Bioscience, 2008The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP
Buxade, Maria +2 more
openaire +4 more sources
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.
Science, 1992Hydrolysis of inositol phospholipids by phospholipase C is initiated by either receptor stimulation or opening of Ca2+ channels. This was once thought to be the sole mechanism to produce the diacylglycerol that links extracellular signals to ...
Y. Nishizuka
semanticscholar +1 more source
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
Current Opinion in Genetics & Development, 1994Signal transduction pathways that respond to external signals through the MAP kinase family of protein kinases are involved in diverse responses in eukaryotic cells. MAP kinases are one element in a series of kinases that serve to connect the plasma membrane with cytoplasmic and nuclear events. MAP kinases have the unusual feature that their activation
openaire +3 more sources
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Biochemical Journal, 2000The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine/threonine-specific protein kinases have been examined against a large panel of protein kinases.
S. Davies +3 more
semanticscholar +1 more source
Studies and perspectives of protein kinase C.
Science, 1986Protein kinase C, an enzyme that is activated by the receptor-mediated hydrolysis of inositol phospholipids, relays information in the form of a variety of extracellular signals across the membrane to regulate many Ca2+-dependent processes.
Y. Nishizuka
semanticscholar +1 more source
Plant MAP kinase kinase kinases structure, classification and evolution
Gene, 1999The increasing number of reports describing plant MAP kinase signalling components reflects the cardinal role that MAP kinase pathways are likely to play during plant growth and development. Relationship and structural analyses of plant MAP kinase kinase kinase related cDNAs and genes established, on one hand, the PMEKKs, which may be distinguished ...
Stefan Jouannic +5 more
openaire +3 more sources
Kinase dysfunction and kinase inhibitors
Veterinary Dermatology, 2013With recent advances in molecular biology, abnormalities in cancer cells that contribute to dysregulation of cell survival and proliferation are being characterized with greater precision. Through this process, key abnormalities in cancer cells involving proteins that regulate signal transduction, migration, mitosis and other critical processes have ...
openaire +3 more sources
Current Opinion in Cell Biology, 1990
Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has ...
C L, Carpenter, L C, Cantley
openaire +3 more sources
Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has ...
C L, Carpenter, L C, Cantley
openaire +3 more sources