Results 361 to 370 of about 3,327,333 (431)
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Kinase inhibitors: the road ahead
Nature Reviews Drug Discovery, 2018Fleur M Ferguson, Nathanael S Gray
exaly +2 more sources
The Protein Kinase Complement of the Human Genome
Science, 2002We have catalogued the protein kinase complement of the human genome (the “kinome”) using public and proprietary genomic, complementary DNA, and expressed sequence tag (EST) sequences.
G. Manning +4 more
semanticscholar +1 more source
MAP kinase kinase kinases and innate immunity
Trends in Immunology, 2006Toll-like receptors, which respond to invariant microbial molecules, and receptors for the proinflammatory cytokines tumour necrosis factor and interleukin-1 are crucial for initiation and regulation of innate immune responses. These receptors activate each of the major mitogen-activated protein (MAP) kinase subtypes, extracellular signal-regulated ...
Sören Beinke +2 more
openaire +3 more sources
The phosphoinositide 3-kinase pathway.
Science, 2002Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components.
L. Cantley
semanticscholar +1 more source
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
Science, 1988In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not through the traditional biochemical approach of protein purification and enzyme assay, but as putative protein kinase amino ...
S. Hanks, A. Quinn, T. Hunter
semanticscholar +1 more source
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
Frontiers in Bioscience, 2008The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case, the a-form possesses a longer C-terminal region than the b-form, which lacks the MAP
Buxade, Maria +2 more
openaire +4 more sources
Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C.
Science, 1992Hydrolysis of inositol phospholipids by phospholipase C is initiated by either receptor stimulation or opening of Ca2+ channels. This was once thought to be the sole mechanism to produce the diacylglycerol that links extracellular signals to ...
Y. Nishizuka
semanticscholar +1 more source
Mechanism of activation of protein kinase B by insulin and IGF‐1.
EMBO Journal, 1996Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase) activity 12‐fold in L6 myotubes, while after transfection into 293 cells PKBalpha was activated 20‐ and 50‐fold in response to insulin and IGF‐1 respectively.
D. Alessi +6 more
semanticscholar +1 more source
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
Current Opinion in Genetics & Development, 1994Signal transduction pathways that respond to external signals through the MAP kinase family of protein kinases are involved in diverse responses in eukaryotic cells. MAP kinases are one element in a series of kinases that serve to connect the plasma membrane with cytoplasmic and nuclear events. MAP kinases have the unusual feature that their activation
openaire +3 more sources
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Biochemical Journal, 2000The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine/threonine-specific protein kinases have been examined against a large panel of protein kinases.
S. Davies +3 more
semanticscholar +1 more source