Results 371 to 380 of about 3,327,333 (431)

Studies and perspectives of protein kinase C.

Science, 1986
Protein kinase C, an enzyme that is activated by the receptor-mediated hydrolysis of inositol phospholipids, relays information in the form of a variety of extracellular signals across the membrane to regulate many Ca2+-dependent processes.
Y. Nishizuka
semanticscholar   +1 more source

Kinase dysfunction and kinase inhibitors

Veterinary Dermatology, 2013
With recent advances in molecular biology, abnormalities in cancer cells that contribute to dysregulation of cell survival and proliferation are being characterized with greater precision. Through this process, key abnormalities in cancer cells involving proteins that regulate signal transduction, migration, mitosis and other critical processes have ...
openaire   +3 more sources

Plant MAP kinase kinase kinases structure, classification and evolution

Gene, 1999
The increasing number of reports describing plant MAP kinase signalling components reflects the cardinal role that MAP kinase pathways are likely to play during plant growth and development. Relationship and structural analyses of plant MAP kinase kinase kinase related cDNAs and genes established, on one hand, the PMEKKs, which may be distinguished ...
Stefan Jouannic, Martin Kreis, Anne-Sophie Leprince, A. Hamal, James Tregear, Yves Henry   +5 more
openaire   +3 more sources

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

Science, 2002
Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes.
G. Johnson, R. Lapadat
semanticscholar   +1 more source

Phosphoinositide kinases

Current Opinion in Cell Biology, 1990
Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has ...
C L, Carpenter, L C, Cantley
openaire   +3 more sources

Kinase Inhibitors:  Not Just for Kinases Anymore

Journal of Medicinal Chemistry, 2003
Kinase inhibitors are widely employed as biological reagents and as leads for drug design. Their use is often complicated by their lack of specificity. Although binding conserved ATP sites accounts for some of their nonspecificity, some compounds inhibit proteins not known to bind ATP.
Susan Lynne McGovern, Brian K. Shoichet
openaire   +3 more sources

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Science, 1996
The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of
Kazushi Kimura, Masa-aki Ito, M. Amano, K. Chihara, Y. Fukata, M. Nakafuku, Bunpei Yamamori, Jianhua Feng, T. Nakano, K. Okawa, A. Iwamatsu, K. Kaibuchi   +11 more
semanticscholar   +1 more source

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1.

Science, 2000
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and ...
F. Urano, Xiaozhong Wang, A. Bertolotti, Yuhong Zhang, Peter Chung, H. Harding, D. Ron   +6 more
semanticscholar   +1 more source

NAK is an IκB kinase-activating kinase

Nature, 2000
Phosphorylation of IkappaB by the IkappaB kinase (IKK) complex is a critical step leading to IkappaB degradation and activation of transcription factor NF-kappaB. The IKK complex contains two catalytic subunits, IKKalpha and IKKbeta, the latter being indispensable for NF-kappaB activation by pro-inflammatory cytokines.
Atsushi Fujimoto, Shigetsugu Hatakeyama, Yuji Nimura, Yi Chen, Yuichiro Tojima, Yoko S. Kaneko, Kyoji Ikeda, Noboru Motoyama, Michael Karin, Mireille Delhase, Keiichi I. Nakayama, Makoto Nakanishi   +11 more
openaire   +2 more sources

Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.

Physiological Reviews, 1999
Mitogen-activated protein kinases (MAPK) are serine-threonine protein kinases that are activated by diverse stimuli ranging from cytokines, growth factors, neurotransmitters, hormones, cellular stress, and cell adherence.
C. Widmann, S. Gibson, M. Jarpe, G. Johnson   +3 more
semanticscholar   +1 more source