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Molecular Configuration, Regulation and Function of Heterochannel Electrical Synapses
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Nature, 2005
Kinesin is a molecular walking machine that organizes cells by hauling packets of components directionally along microtubules. The physical mechanism that impels directional stepping is uncertain. We show here that, under very high backward loads, the intrinsic directional bias in kinesin stepping can be reversed such that the motor walks sustainedly ...
Robert A. Cross, Nicholas J Carter
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Kinesin is a molecular walking machine that organizes cells by hauling packets of components directionally along microtubules. The physical mechanism that impels directional stepping is uncertain. We show here that, under very high backward loads, the intrinsic directional bias in kinesin stepping can be reversed such that the motor walks sustainedly ...
Robert A. Cross, Nicholas J Carter
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Kinesin superfamily motor proteins and intracellular transport
Nature Reviews Molecular Cell Biology, 2009Nobutaka Hirokawa +2 more
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Structures of kinesin and kinesin–microtubule interactions
Current Opinion in Cell Biology, 1999Several X-ray crystal structures of kinesin motor domains have recently been solved at high resolution ( approximately 0.2-0.3 nm), in both their monomeric and dimeric states. They show the folding of the polypeptide chain and different arrangements of subunits in the dimer.
Mandelkow, Eckhard, Hoenger, Andreas
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Current Opinion in Cell Biology, 2006
Kinesin-1 is a single-molecule walking machine, driven by ATP turnover. Recent optical trapping experiments show that pulling backwards on a walking kinesin-1 molecule causes the mechanical walking action to reverse, while the coupled chemical cycle of ATP turnover continues, apparently, to run forwards -- kinesin can moonwalk.
Nicholas J Carter, Robert A. Cross
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Kinesin-1 is a single-molecule walking machine, driven by ATP turnover. Recent optical trapping experiments show that pulling backwards on a walking kinesin-1 molecule causes the mechanical walking action to reverse, while the coupled chemical cycle of ATP turnover continues, apparently, to run forwards -- kinesin can moonwalk.
Nicholas J Carter, Robert A. Cross
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Nature Reviews Cancer, 2012
Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development.
Frank Kozielski, Oliver Rath
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Kinesins are a family of molecular motors that travel unidirectionally along microtubule tracks to fulfil their many roles in intracellular transport or cell division. Over the past few years kinesins that are involved in mitosis have emerged as potential targets for cancer drug development.
Frank Kozielski, Oliver Rath
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Structure of a kinesin–tubulin complex and implications for kinesin motility
Nature Structural & Molecular Biology, 2013The typical function of kinesins is to transport cargo along microtubules. Binding of ATP to microtubule-attached motile kinesins leads to cargo displacement. To better understand the nature of the conformational changes that lead to the power stroke that moves a kinesin's load along a microtubule, we determined the X-ray structure of human kinesin-1 ...
Marcel Knossow +9 more
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Kinesin-II, the heteromeric kinesin
Cellular and Molecular Life Sciences (CMLS), 1999The kinesins constitute a large family of motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. One class of these molecular motors, kinesin-II, is unique in that these proteins are typically found as heterotrimeric complexes containing two different, though related,
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