Results 241 to 250 of about 25,177 (273)
Single-Molecule Fluorescence and in Vivo Optical Traps: How Multiple Dyneins and Kinesins Interact
Chemical Reviews, 2014 Paul R Selvin
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Kinesins: Motor Proteins as Novel Target for the Treatment of Chronic Pain
Molecular Neurobiology, 2018Dilip Sharma +2 more
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Structure of a kinesin–tubulin complex and implications for kinesin motility
Nature Structural & Molecular Biology, 2013The typical function of kinesins is to transport cargo along microtubules. Binding of ATP to microtubule-attached motile kinesins leads to cargo displacement. To better understand the nature of the conformational changes that lead to the power stroke that moves a kinesin's load along a microtubule, we determined the X-ray structure of human kinesin-1 ...
Gigant, Benoît +7 more
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Roles of mitotic kinesins, kinesin-5 and kinesin-6, in regulating neuronal migation
2022Mammalian brain development depends on migration of newborn neurons from their sites of origin to new locales. Migration of the neuron involves the extension of a leading process followed by somal translocation. According to the existing literature, cytoplasmic dynein and myosin-II, a microtubule-based motor and an actin-based motor, respectively ...
Aditi Falnikar +2 more
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Trends in Biochemical Sciences, 2001
Conventional kinesin has long been known to be a molecular motor that transports vesicular cargo, but only recently have we begun to understand how it functions in cells. Regulation of kinesin involves self-inhibition in which a head-to-tail interaction prevents microtubule binding.
K J, Verhey, T A, Rapoport
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Conventional kinesin has long been known to be a molecular motor that transports vesicular cargo, but only recently have we begun to understand how it functions in cells. Regulation of kinesin involves self-inhibition in which a head-to-tail interaction prevents microtubule binding.
K J, Verhey, T A, Rapoport
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Biochemistry, 2007
Several lines of experimental evidence suggest that the conventional kinesin 1 walks by an asymmetric hand-over-hand mechanism, although it is a homodimer. In the previous study, we examined several important force-dependent features of the hand-over-hand mechanism of kinesin. In this study, we focus on the asymmetry in the hand-over-hand mechanism. We
Qiang, Shao, Yi Qin, Gao
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Several lines of experimental evidence suggest that the conventional kinesin 1 walks by an asymmetric hand-over-hand mechanism, although it is a homodimer. In the previous study, we examined several important force-dependent features of the hand-over-hand mechanism of kinesin. In this study, we focus on the asymmetry in the hand-over-hand mechanism. We
Qiang, Shao, Yi Qin, Gao
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Trends in Cell Biology, 2002
Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a diverse family of kinesins, members of which differ in composition and functions.
Mandelkow, Eckhard, Mandelkow, Eva-Maria
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Kinesins are motor proteins that move cargoes such as vesicles, organelles and chromosomes along microtubules. They are best known for their role in axonal transport and in mitosis. There is a diverse family of kinesins, members of which differ in composition and functions.
Mandelkow, Eckhard, Mandelkow, Eva-Maria
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The Mechanochemistry of Kinesin
Molecular and Chemical Neuropathology, 1990The mechanochemical protein kinesin is believed to play an important role in intracellular vesicle movements, including the anterograde motion of axoplasmic transport. This article reviews some of the pharmacological and biochemical information about kinesin, particularly with respect to the properties of nucleotide-dependent microtubule binding ...
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Nature, 2005
Kinesin is a molecular walking machine that organizes cells by hauling packets of components directionally along microtubules. The physical mechanism that impels directional stepping is uncertain. We show here that, under very high backward loads, the intrinsic directional bias in kinesin stepping can be reversed such that the motor walks sustainedly ...
N J, Carter, R A, Cross
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Kinesin is a molecular walking machine that organizes cells by hauling packets of components directionally along microtubules. The physical mechanism that impels directional stepping is uncertain. We show here that, under very high backward loads, the intrinsic directional bias in kinesin stepping can be reversed such that the motor walks sustainedly ...
N J, Carter, R A, Cross
openaire +2 more sources