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Trends in Plant Science, 2000
Kinetochores are large protein complexes that bind to centromeres. By interacting with microtubules and their associated motor proteins, kinetochores both generate and regulate chromosome movement. Kinetochores also function in the spindle checkpoint; a surveillance mechanism that ensures that metaphase is complete before anaphase begins.
Hong-Guo Yu +3 more
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Kinetochores are large protein complexes that bind to centromeres. By interacting with microtubules and their associated motor proteins, kinetochores both generate and regulate chromosome movement. Kinetochores also function in the spindle checkpoint; a surveillance mechanism that ensures that metaphase is complete before anaphase begins.
Hong-Guo Yu +3 more
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Biochemical Society Transactions, 2006 The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby promoting organization of mitotic ...
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Spindles and Kinetochores [PDF]
Nature New Biology, 1971 Cellular Mechanisms of Chromosome Distribution by Peter Luykx. (International Review of Cytology, Supplement 2.) Pp. vii+173. (Academic: New York and London, September 1970.) 112s.
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Centromeres and kinetochores of Brassicaceae
Chromosome Research, 2014The centromere-the primary constriction of monocentric chromosomes-is essential for correct segregation of chromosomes during mitosis and meiosis. Centromeric DNA varies between different organisms in sequence composition and extension. The main components of centromeric and pericentromeric DNA of Brassicaceae species are centromeric satellite repeats.
Michael Sandmann +2 more
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The structure of a primitive kinetochore
Trends in Biochemical Sciences, 1989The isolation of yeast centromeres has provided the opportunity to describe the molecular structure of chromosome attachments to the mitotic spindle. Nucleolytic probes of chromatin structure and construction of conditional mutants in centromere function have been used to study the regulation and assembly of centromeres throughout the cell cycle in ...
Alison Presmanes Hill +3 more
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Nature Cell Biology, 2003
The most interesting discoveries are often those that couple distinct fields of science in unexpected ways. The marriage of the nuclear pore complex to the kinetochore and spindle checkpoint regulation is a recent example, raising the question of why such divergent processes as mitosis and nuclear transport use common proteins.
Ian G. Macara, P. Todd Stukenberg
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The most interesting discoveries are often those that couple distinct fields of science in unexpected ways. The marriage of the nuclear pore complex to the kinetochore and spindle checkpoint regulation is a recent example, raising the question of why such divergent processes as mitosis and nuclear transport use common proteins.
Ian G. Macara, P. Todd Stukenberg
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Kinetochore structure and function
Trends in Cell Biology, 2005The vertebrate kinetochore is a complex structure that specifies the attachments between the chromosomes and microtubules of the spindle and is thus essential for accurate chromosome segregation. Kinetochores are assembled on centromeric chromatin through complex pathways that are coordinated with the cell cycle.
Gordon K. Chan, Song-Tao Liu, Tim J. Yen
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The kinetochores of Caenorhabditis elegans
Chromosoma, 1982Light microscopy of the mitotic chromosomes of Caenorhabditis elegans suggests that non-localized kinetochores are present, since the chromosomes appear as stiff rods 1 to 2 micrometers in length and lack any visible constriction. The holokinetic structure was confirmed by reconstructions of electron micrographs of dividing nuclei in serially sectioned
J. Nichol Thomson +2 more
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The Formation, Structure, and Composition of the Mammalian Kinetochore and Kinetochore Fiber
1982Publisher Summary Advances in the understanding of the formation, structure, and chemistry of the mammalian kinetochore and its associated fiber are summarized in the chapter. The initiation of chromosome movement during cell division can be correlated with the formation of a fiber, composed primarily of microtubules (MTs) and associated proteins ...
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Evolving Centromeres and Kinetochores
2017The genetic material, contained on chromosomes, is often described as the "blueprint for life." During nuclear division, the chromosomes are pulled into each of the two daughter nuclei by the coordination of spindle microtubules, kinetochores, centromeres, and chromatin.
Steven Friedman, Michael Freitag
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