Results 231 to 240 of about 115,854 (373)

Nuclear destabilisation – a possible genesis of cancer?

Biological Reviews, EarlyView.
ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott, Francesco Bettariga, Marco Ventin, Chris Bishop, Britta Stordal   +4 more
wiley   +1 more source

Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface

Science, 2018
S. Jenni, S. Harrison
semanticscholar   +1 more source

Canonical and Non‐Canonical Functions of Histone H3K4 Methylation Modifiers in Cancer

Cancer Science, EarlyView.
Histone H3K4‐modifying enzymes regulate gene expression and cellular processes critical to cancer development. Beyond their canonical roles, these enzymes also exhibit non‐catalytic and non‐histone functions, offering new opportunities for therapeutic intervention. ABSTRACT Histone H3K4 modifications are altered in the regulation of gene expression and
Takayuki Hoshii
wiley   +1 more source

ACTN4 Gene Amplification and Actinin‐4 Protein Expression for Osimertinib Efficacy in EGFR‐Mutant NSCLC

Cancer Science, EarlyView.
ABSTRACT Actinin‐4 (gene name: ACTN4) is an actin‐bundling protein implicated in cancer invasion and metastasis. This study evaluated whether ACTN4 amplification and actinin‐4 protein expression were associated with osimertinib efficacy in epidermal growth factor receptor‐mutant non‐small cell lung cancer.
Takehiro Tozuka, Rintaro Noro, Yutaka Naito, Nami Miura, Shinobu Kunugi, Kazufumi Honda, Masahiro Seike   +6 more
wiley   +1 more source

Deletion of the Mis12C‐Binding Domain of CENP‐C Promotes Chromosomal Aneuploidy in Cutaneous Squamous Cell Carcinoma

Cancer Science, EarlyView.
M12BD deficiency increases a chromosomal aneuploidy, particularly trisomy of chromosomes 6 and 10. ABSTRACT CENP‐C, an essential component of the kinetochore, connects centromeric chromatin to the outer kinetochore, and thereby ensures accurate chromosome segregation.
Megumi Saito, Kazuhiro Okumura, Yurika Tokunaga, Sora Tanaka, Keisuke Otoyama, Yoshinori Hasegawa, Masatoshi Hara, Masakazu Hashimoto, Toshihiko Fujimori, Tatsuo Fukagawa, Yuichi Wakabayashi   +10 more
wiley   +1 more source

Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes [PDF]

, 2000
Naoko Yoshizawa-Sugata
openalex   +1 more source

Six New Cases of 22q13.2 Gain Including TFC20: First Report of Triplication and Smallest Duplication Associated With Neurodevelopmental Delays

Clinical Genetics, EarlyView.
This study reports six new cases of 22q13.2 duplication and triplication, including the TCF20 gene, associated with neurodevelopmental disorders and various morphological and systemic abnormalities. The findings suggest a variable expressivity, but their complete penetrance remains uncertain compared to well‐established loss‐of‐function variants ...
Etienne Bizot, Dima Jouni, Caroline Rooryck, Juliet Taylor, Marine Legendre, Lorelei Charbonnier, Julia Metreau, Emmanuelle Benaloun, Audrey Pinson, Geneviève Quenum, Jérôme Bouligand, Gérard Tachdjian, Philippe Labrune, Lucie Tosca   +13 more
wiley   +1 more source

The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes

, 2000
Yutong Xue, Julie C. Canman, Cheol-Soon Lee, Zuqin Nie, Dafeng Yang, G. Tony Moreno, Mary K. Young, Edward D. Salmon, Weidong Wang   +8 more
openalex   +3 more sources

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona. [PDF]

Sci Adv
Cmentowski V, Musacchio A.
europepmc   +1 more source

White–Sutton Syndrome: Insight of an Italian Cohort of 19 Subjects

Clinical Genetics, EarlyView.
New insights into White–Sutton syndrome with a collection of 19 Italian patients. Due to its complexity, we stress the importance of a systematic evaluation following the diagnosis and a thoughtful management of patients. Preliminary genotype–phenotype correlation analysis suggests the association between disruptive splicing variants and more severe ...
Anna Facchini, Maria Pina Concas, Stefania Zampieri, Iris Scala, Claudio Graziano, Anna Maria Innoceta, Marina Trivisano, Angela De Dominicis, Gabriele Trimarchi, Livia Garavelli, Margherita Baldassarri, Ilaria De Maggio, Francesca Mari, Donatella Greco, Paolo Gasparini   +14 more
wiley   +1 more source