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Metabolism and Functions of Trypanothione in the Kinetoplastida

Annual Review of Microbiology, 1992
Trypanosomatids differ from all other organisms in their ability to conjugate the sulfur-containing tripeptide, glutathione, and the polyamine, spermidine, to form trypanothione [N1,N8-bis(glutathionyl)spermidine]. Together with the NADPH-dependent flavoprotein, trypanothione reductase, the dithiol form of trypanothione provides an intracellular ...
Alan H Fairlamb
exaly   +4 more sources

Ichthyobodo necator (Kinetoplastida)-a complex of sibling species [PDF]

Diseases of Aquatic Organisms, 2004
Ichthyobodo necator is a parasitic flagellate that attacks fishes, causing disease problems in freshwater worldwide. Findings of similar flagellates in strictly marine fishes have indicated that ichthyobodiosis may be caused by more than 1 flagellate species.
Shigehiko Urawa
exaly   +3 more sources

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UMP synthesis in the kinetoplastida

Biochimica et Biophysica Acta (BBA) - General Subjects, 1982
All six enzymes of pyrimidine biosynthesis de novo have been detected in homogenates of the culture promastigote form of Leishmania mexicana amazonensis, the blood trypomastigote form of Trypanosoma brucei and the culture epimastigote, blood trypomastigote and intracellular amastigote forms of Trypanosoma cruzi.
D J, Hammond, W E, Gutteridge
openaire   +2 more sources

Genetic Manipulation of Kinetoplastida

Parasitology Today, 1999
During the 1980s, many kinetoplastid genes were cloned and their function inferred from homology with genes from other organisms, location of the corresponding proteins or expression in heterologous systems. Up until 1990, before the availability of DNA transfection methodology, we could not analyze the function of kinetoplastid genes within the ...
openaire   +2 more sources

Proliferative opisthomastigote forms in Herpetomonas roitmani (Kinetoplastida: Trypanosomatidae)

Parasitology Research, 1996
The flagellate Herpetomonas roitmani is a symbiont-bearing trypanosomatid that spontaneously differentiates from promastigote to para- and opisthomastigote forms when maintained in axenic culture medium. Thus, after cultivation for 72 h at 28 degrees C, 37% of the total number of cells are in the opisthomastigote form.
P M, Faria-e-Silva, M J, Soares, W, de Souza   +2 more
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Structure, function, and biogenesis of glycosomes in Kinetoplastida

Journal of Bioenergetics and Biomembranes, 1994
Glycosomes are intracellular, microbody-like organelles found in all members of the protist order Kinetoplastida examined. Nine enzymes involved in glucose and glycerol metabolism are associated with these organelles. These enzymes are involved in pathways which, in other organisms, are usually located in the cytosol.
V, Hannaert, P A, Michels
openaire   +2 more sources

Kinetoplastidae display naturally occurring ancillary DNA-containing structures

Molecular and Biochemical Parasitology, 1994
Kinetoplast-derived, DNA-containing structures were found in several members of the order Kinetoplastida. The structures, for which we propose the name ancillary DNA-containing structures (aDNA), were discovered during the course of low-light-level video fluorescence microscopy studies using several nucleic acid-specific fluorescent reagents.
Y, Miyahira, J A, Dvorak
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Polymorphism in the subtelomeric regions of chromosomes of Kinetoplastida

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2002
Leishmania spp. and the related kinetoplastid Trypanosoma brucei are single-celled parasites. In Leishmania, the nuclear genome comprises 36 diploid chromosomes and occasional amplified minichromosomes, while the T. brucei nucleus contains 11 larger diploid chromosomes and a variable number of intermediate-sized and minichromosomes.
Guoliang, Fu, Sara E, Melville
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The paraflagellar rod of kinetoplastida: Solved and unsolved questions

Parasitology Today, 1996
The flagellum of almost every member of the Kinetoplastida contains, next to its canonical 'nine-plus-two' axoneme, structure, a unique, complex and highly organized lattice-like structure called the paraflagellar rod or paraxial rod. Here, Philippe Bastin, Keith Matthews and Keith Gull summarize the latest findings on its structure, the nature of its ...
Bastin, P, Matthews, K, Gull, K
exaly   +3 more sources

The cell surface charge of Bodo sp. (Kinetoplastida: Bodonidae)

European Journal of Protistology, 1993
Cytochemistry, using cationized ferritin particles at pH 7.2 and colloidal iron particles at pH 1.8, and cell electrophoresis were used to analyze the surface charge of the protozoan Bodo sp. Surface anionic sites are homogeneously distributed throughout the protozoan surface, including the flagella, the cytostome and the flagellar pocket.
R C, Vommaro, M, Attias, W, De Souza
openaire   +2 more sources