Results 131 to 140 of about 16,601 (180)

Hydroxylated Kininogens and Kinins

1992
Hydroxyprolyl-3-bradykinin was identified in the digest of purified human high molecular weight (H) kininogen with plasma kallikrein. Hydroxyproline was not detected in the heavy and light chains portions of H kininogen, although they include three possible sites for hydroxylation of proline by proline hydroxylase.
H, Kato, K, Enjyoji
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Kininogen Deficiency in the Rat

1992
The Brown Norway Katholiek (B/N-Ka) strain rat is the only animal strain that demonstrates deficiency in plasma HMW- and LMW-kininogens with a low level of prekallikrein. We developed an RIA for rat HMW-kininogen, LMW-kininogen, and T-kininogen, and using them measured these proteins in B/N-Ka and normal strain (B/N-Ki) rats.
S, Oh-ishi, I, Hayashi, K, Yamaki, I, Utsunomiya   +3 more
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The Role of T-Kininogen and H and L Kininogens in Health and Disease

1989
Until recently, the classical kallikrein-kinin system has been thought of as the major system in all species which is involved in the immediate cascade of bradykinin and other mediators in the inflammatory response. One historical fact that indicated that kallikrein may not be the liberator of kinins in all species was the published finding by Fasciola
L M, Greenbaum, C, Cho, A, Barlas
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Structure and functions of human kininogens

Trends in Pharmacological Sciences, 1991
Evidence has accumulated over the past three decades implicating plasma kininogens in numerous inflammatory processes. Delineation of the detailed biochemistry and, more recently, the molecular biology of the human kininogens has resulted in a deeper understanding of the structure-function correlations of the human kininogens. Studies of alterations of
R A, DeLa Cadena, R W, Colman
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Kininogen in Tumor-Bearing Mice

1989
Three types of kininogens have been found so far in mammalian species which differ by molecular weight and susceptibility to the various kinino-genases. Two of them are present throughout the mammalian lineage, while the third type, termed T-kininogen, has been considered to be unique for the rat. Although kininogens have recently been identified to be
H, Okamoto, N, Itoh, M, Uwani, S, Yokota, A, Hatta   +4 more
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A Preparation of Kininogen for the Assay of Kallikreins

Thrombosis and Haemostasis, 1966
SummaryA method by which a kininogen preparation free of kallikrein and freed of inhibitors of the kininogenic system is described. The preparation can be used for the quantitative estimation of plasma or salivary kallikrein in the presence of active factors of the fibrinolytic system, since in such a preparation freed of kallikreinogen neither the ...
M, Malofiejew, K, Buluk, M, Czokalo
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Kinins and kininogen in endotoxin shock

Experientia, 1970
Aucune quantite detectable de kinines ne fut trouvee apres administration d'endotoxine et l'on n'obtint pas de difference significative dans le contenu plasmatique en kininogenes apres l'injection. Nos resultats n'attribuent aux kinines aucune participation significative a l'hypotension du choc endotoxique.
O A, Carretero, A, Nasjletti, J C, Fasciolo   +2 more
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Rapid isolation of human kininogens

Thrombosis Research, 1987
A rapid, two-step procedure is described for the isolation of both "high molecular weight" (H-) and "low molecular weight" (L-) plasma kininogens from a single sample of plasma. Affinity chromatography on carboxymethyl-papain-Sepharose is used, together with high-resolution anion exchange chromatography.
Johnson, David A., Salvesen, Guy, Brown, Molly A., Barrett, Alan J.   +3 more
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Control of Kininogen Gene Expression

1989
Kininogens are precursor proteins of bradykinin that are widely distributed in mammalian blood plasma1-3. Kininogens are comprised of two distinct proteins, designated low molecular weight (LMW) and high molecular weight (HMW) kininogens. Both kininogens are single-chain glycoproteins and carry a bradykinin moiety in the interior of the polypeptide ...
S, Nakanishi, N, Kitamura, H, Ohkubo, A, Kakizuka, R, Kageyama, Y, Masu, K, Nakayama   +6 more
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[DNA analysis for the kininogen gene of patients with kininogen deficiency in Japan].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 1990
The kininogen (KGN) gene status was examined in 4 families with both high molecular weight (HMW) and low molecular weight (LMW) KGM deficiency and one family with only HMW-KGN deficiency reported in Japan. No abnormal HMW-KGN or LMW-KGN was detected in those with these deficiencies by immunoblot analysis using monoclonal antibodies (HKG-H12, HKG-L7 ...
H, Hayashi, F, Ishimaru, T, Fujita, N, Tsurumi, T, Tsuda, I, Kimura   +5 more
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